| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HsT18964 |
| WB Predicted band size | 133 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ITGA11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ITGA11抗体的代表性文献摘要概括(虚拟示例，仅供参考)：
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1. **文献名称**: *Integrin α11 antibodies inhibit collagen remodeling in fibrosis models*
**作者**: Smith A, et al.
**摘要**: 本研究开发了靶向ITGA11的单克隆抗体，验证其在肺纤维化小鼠模型中通过阻断胶原结合能力抑制成纤维细胞活化，降低胶原沉积的疗效。
2. **文献名称**: *ITGA11 as a novel biomarker in triple-negative breast cancer*
**作者**: Chen L & Park H.
**摘要**: 利用人源化ITGA11抗体进行免疫组化分析，发现ITGA11在TNBC肿瘤基质中高表达，与患者预后不良相关，提示其作为治疗靶点的潜力。
3. **文献名称**: *A high-affinity rabbit monoclonal antibody for integrin α11 functional studies*
**作者**: Müller R, et al.
**摘要**: 报道了一种兔源ITGA11单克隆抗体的开发，通过流式细胞术和共聚焦显微技术证实其特异性，并证明其可抑制肿瘤细胞迁移和血管生成。
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注：以上为模拟摘要，实际文献需通过PubMed/Google Scholar等平台检索关键词(如"ITGA11 antibody"、"integrin alpha11 therapeutic")获取。如需真实文献推荐，请提供具体研究场景。
The ITGA11 antibody targets integrin alpha-11 (ITGA11), a transmembrane receptor subunit that pairs with integrin beta-1 (ITGB1) to form the α11β1 integrin heterodimer. Integrins mediate cell-extracellular matrix (ECM) interactions, influencing cell adhesion, migration, and signaling. ITGA11 is primarily expressed in mesenchymal stromal cells, fibroblasts, and certain cancer-associated stromal cells, where it binds collagen and laminin in the ECM. Its function is linked to tissue remodeling, fibrosis, and tumor microenvironment regulation.
Research highlights ITGA11's role in pathological conditions, including cancer progression, fibrosis (e.g., lung, liver), and wound healing. In tumors, ITGA11 in stromal fibroblasts promotes invasive growth and metastasis by modulating ECM stiffness and activating pro-tumorigenic signaling pathways like TGF-β. Antibodies against ITGA11 are vital tools for detecting its expression in tissues, studying its mechanistic contributions to diseases, and exploring therapeutic targeting. For example, blocking ITGA11 with antibodies has shown potential in preclinical models to reduce fibrosis and inhibit tumor-stroma interactions.
ITGA11 antibodies are used in techniques like immunohistochemistry, flow cytometry, and Western blotting. Their development supports translational research aimed at disrupting integrin-mediated ECM dysregulation in fibrotic diseases and cancers.
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