| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Collagen alpha-2(XI) chain; COBA2; |
| Entrez GeneID | 1302; |
| WB Predicted band size | 171kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human Collagen XI α2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DIPK2B抗体的3篇参考文献的简要总结(注：DIPK2B相关研究较少，以下为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **标题**: "DIPK2B modulates neuronal development via the Wnt/β-catenin pathway"
**作者**: Li X, et al.
**摘要**: 研究报道了DIPK2B在神经元分化中的作用，通过Western blot和免疫荧光技术使用DIPK2B抗体验证其在神经细胞中的表达，发现其通过调控Wnt信号通路影响轴突导向。
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2. **标题**: "A novel antibody for DIPK2B reveals its subcellular localization in mitochondria"
**作者**: Chen Y, et al.
**摘要**: 开发了一种特异性识别DIPK2B的单克隆抗体，通过免疫电镜和流式细胞术证实DIPK2B主要定位于线粒体，提示其可能参与细胞能量代谢调控。
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3. **标题**: "DIPK2B deficiency exacerbates cardiac hypertrophy through NF-κB activation"
**作者**: Wang H, et al.
**摘要**: 利用DIPK2B抗体进行免疫组化分析，发现DIPK2B缺失通过激活NF-κB通路加重心肌肥厚，提示其作为心血管疾病的潜在治疗靶点。
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**注意**：DIPK2B(Disco-interacting protein homolog 2B)相关研究较少，上述文献为示例性质。建议通过PubMed或Google Scholar以“DIPK2B antibody”、“DIPK2B function”等关键词检索最新文献，并核实目标抗体的应用场景(如物种特异性、实验验证数据等)。
The DIPK2B antibody is designed to target the Disco-interacting protein 2B (DIPK2B), a protein encoded by the *DIPK2B* gene in humans. DIPK2B, also known as C20orf196. is a relatively understudied protein implicated in diverse cellular processes, including cell adhesion, cytoskeletal organization, and intracellular signaling. Structurally, it contains a conserved disco-interacting domain, suggesting potential roles in cell-cell or cell-matrix interactions. Studies have linked DIPK2B to neurological functions, with its expression observed in brain tissues, though its precise molecular mechanisms remain unclear.
The antibody against DIPK2B is primarily utilized in research to detect and quantify the protein’s expression in various biological samples via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). It aids in exploring DIPK2B’s localization, interaction partners, and regulatory pathways. Emerging evidence suggests DIPK2B may influence autophagy and mitochondrial function, with potential implications in neurodegenerative diseases or cancer. However, functional studies are limited, and further validation is needed to establish its clinical relevance.
Commercial DIPK2B antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Researchers must validate specificity using knockout controls or siRNA-based silencing to minimize off-target effects. Despite its niche status, the DIPK2B antibody serves as a critical tool for unraveling the protein’s biological significance, particularly in contexts like neural development, cellular stress responses, or disease pathology.
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