| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human MAPK13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAPK13抗体的3篇参考文献(虚拟示例，实际文献需根据数据库检索)：
1. **文献名称**: "MAPK13 regulates inflammatory responses in macrophages via phosphorylation of c-Fos"
**作者**: Li X, Chen Y, et al.
**摘要**: 研究通过Western blot和免疫荧光技术，利用MAPK13特异性抗体证实MAPK13在巨噬细胞中的激活可调控炎症因子表达，揭示其通过磷酸化c-Fos参与炎症反应机制。
2. **文献名称**: "Targeting MAPK13 in Alzheimer's disease: Antibody-based inhibition reduces tau hyperphosphorylation"
**作者**: Smith J, Wang H, et al.
**摘要**: 使用MAPK13抗体在小鼠模型中检测到该激酶在脑组织中的高表达，并通过抗体阻断实验证明抑制MAPK13活性可降低tau蛋白异常磷酸化，提示其作为阿尔茨海默病治疗靶点。
3. **文献名称**: "MAPK13 antibody validation in human osteoarthritis synovial tissues"
**作者**: Rodriguez A, Kim S, et al.
**摘要**: 研究通过免疫组化验证了MAPK13抗体在人类骨关节炎滑膜组织中的特异性，发现MAPK13表达水平与关节炎症程度正相关，提示其在疾病进展中的作用。
注：以上为模拟内容，实际文献需在PubMed、Web of Science等平台检索关键词"MAPK13 antibody"或"p38δ MAPK"，并筛选应用该抗体的功能研究类论文。
The mitogen-activated protein kinase 13 (MAPK13), also known as p38δ, belongs to the p38 MAPK family, which regulates cellular responses to stress, inflammation, apoptosis, and differentiation. MAPK13 is activated by dual phosphorylation at Thr180 and Tyr182 within its activation loop, typically through upstream kinases like MKK3/6. It shares structural homology with other p38 isoforms (α, β, γ) but exhibits distinct tissue expression patterns, with higher levels in epithelial tissues, lungs, and secretory glands.
MAPK13-specific antibodies are critical tools for studying its expression, localization, and activation in physiological and pathological contexts. These antibodies are designed to detect either total MAPK13 or its phosphorylated (active) form, enabling research into signaling dynamics. Applications include Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. Validated antibodies help explore MAPK13's role in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. For example, MAPK13 is implicated in tumor progression, chronic obstructive pulmonary disease (COPD), and skin inflammation, making it a potential therapeutic target.
Antibody specificity is ensured through knockout controls or peptide competition assays. Researchers rely on these reagents to dissect MAPK13's interactions with substrates and its regulation by inhibitors, advancing drug discovery and mechanistic studies.
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