| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | T3JAM |
| WB Predicted band size | 64 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TRAF3IP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于TRAF3IP3抗体的3篇参考文献的简单列举(注：文献信息为模拟示例，实际文献需通过数据库验证)：
1. **标题**：*TRAF3IP3 regulates innate immune responses via NF-κB signaling*
**作者**：Li, X. et al.
**摘要**：该研究利用TRAF3IP3特异性抗体，通过免疫沉淀和Western blot技术，揭示了TRAF3IP3在巨噬细胞中通过调控TRAF3/NF-κB通路介导炎症因子产生的机制。
2. **标题**：*TRAF3IP3 is a novel biomarker in systemic lupus erythematosus*
**作者**：Wang, Y. et al.
**摘要**：通过抗体验证，发现TRAF3IP3在红斑狼疮患者外周血单核细胞中高表达，并与其疾病活动度相关，提示其可能作为自身免疫疾病的潜在治疗靶点。
3. **标题**：*Structural characterization of TRAF3IP3 using monoclonal antibodies*
**作者**：Smith, J. et al.
**摘要**：研究开发了高特异性TRAF3IP3单克隆抗体，结合冷冻电镜技术解析了TRAF3IP3的蛋白结构，阐明了其与TRAF3结合的分子基础。
4. **标题**：*TRAF3IP3 modulates B-cell receptor signaling and antibody production*
**作者**：Chen, Z. et al.
**摘要**：使用TRAF3IP3抗体进行免疫荧光和流式分析，证明其在B细胞活化中调控抗原受体信号传导，影响抗体分泌及免疫应答效率。
(注：以上为基于领域知识的模拟文献，实际引用请通过PubMed/Google Scholar等平台检索真实文献。)
**Background of TRAF3IP3 Antibody**
The TRAF3-interacting protein 3 (TRAF3IP3), also known as AZI2 or NAP1. is a cytoplasmic adaptor protein involved in innate immune signaling pathways. It interacts with TRAF3. a critical mediator in Toll-like receptor (TLR) and RIG-I-like receptor (RLR) signaling, facilitating the activation of transcription factors like IRF3 and NF-κB to induce type I interferons (IFNs) and proinflammatory cytokines. TRAF3IP3 contains an N-terminal CARD (caspase activation and recruitment domain) and a C-terminal TRAF-binding domain, enabling its role in bridging upstream sensors (e.g., MAVS) and downstream signaling complexes.
Antibodies targeting TRAF3IP3 are essential tools for studying its expression, localization, and interactions in immune regulation. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate TRAF3IP3’s involvement in antiviral responses, autoimmune diseases, and cancer. For instance, TRAF3IP3 dysregulation has been linked to pathologies like lupus and viral evasion mechanisms. Researchers rely on validated TRAF3IP3 antibodies to ensure specificity, often employing knockout cell lines as controls. These antibodies help unravel molecular mechanisms in immune signaling and potential therapeutic targets, highlighting their importance in both basic and translational research.
×
