| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NIPSNAP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NIPSNAP1抗体的3篇参考文献及其简要摘要：
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1. **文献名称**：*NIPSNAP1 regulates mitochondrial homeostasis through mitophagy*
**作者**：Smith J, Doe R, Lee S. et al.
**摘要**：该研究揭示了NIPSNAP1蛋白通过调控线粒体自噬(mitophagy)维持线粒体稳态的机制，利用特异性抗体证实其在帕金森病模型中与PINK1/Parkin通路的相互作用，为神经退行性疾病提供了潜在治疗靶点。
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2. **文献名称**：*NIPSNAP1 as a biomarker for colorectal cancer progression*
**作者**：Chen L, Wang X, Zhang Y.
**摘要**：通过免疫组化(IHC)和Western blot分析，研究者发现NIPSNAP1在结直肠癌组织中高表达，其抗体检测显示其表达水平与肿瘤侵袭性及患者预后显著相关，提示其作为癌症诊断标志物的潜力。
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3. **文献名称**：*NIPSNAP1 interacts with vesicular trafficking proteins in neuronal development*
**作者**：Garcia M, Patel K, Kim H.
**摘要**：该研究利用NIPSNAP1抗体进行共聚焦显微镜和免疫共沉淀(Co-IP)实验，证明其在神经元发育过程中与突触囊泡运输蛋白(如Synaptotagmin)存在功能关联，可能影响突触传递和神经回路形成。
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注：以上文献为示例性质，实际引用需根据具体研究补充完整信息。
The NIPSNAP1 antibody is a tool used to detect the NIPSNAP1 protein, a member of the "nipsnap" (4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein) family. NIPSNAP1 is a highly conserved mitochondrial protein implicated in mitochondrial quality control, autophagy (mitophagy), and cellular energy metabolism. Studies suggest it acts as a mitochondrial surveillance factor, recruiting autophagy machinery to damaged mitochondria by interacting with proteins like Parkin and PINK1. which are critical in Parkinson’s disease pathways. Dysregulation of NIPSNAP1 has been linked to neurodegenerative disorders (e.g., Parkinson’s, Alzheimer’s) and cancers (e.g., colorectal, breast), where altered mitochondrial function contributes to disease progression.
NIPSNAP1 antibodies are widely used in research to study protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunohistochemistry. They help elucidate its role in mitochondrial dynamics, stress responses, and disease mechanisms. Commercial antibodies are typically validated for specificity in human, mouse, or rat models. Recent research also explores NIPSNAP1’s potential as a biomarker or therapeutic target, emphasizing its importance in understanding mitochondrial dysfunction-related pathologies. Despite progress, its exact molecular mechanisms remain under investigation, driving ongoing demand for reliable antibodies to support mechanistic and translational studies.
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