| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HBO1; HBOA; MYST2; ZC2HC7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human KAT7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与KAT7抗体相关的文献摘要信息，供参考：
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1. **文献名称**：KAT7 is a genetic vulnerability of MYC-driven cancer cells
**作者**：Hogg SJ, et al.
**摘要**：研究通过CRISPR筛选发现KAT7是MYC高表达肿瘤细胞的生存必需基因。文中使用KAT7抗体进行ChIP-seq和Western blot验证，证明抑制KAT7可降低组蛋白H3K14乙酰化水平，诱导癌细胞衰老。
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2. **文献名称**：A role for KAT7 in cell cycle progression and hepatocellular carcinoma
**作者**：Li X, et al.
**摘要**：该研究揭示了KAT7通过乙酰化H4K5调控细胞周期蛋白表达。作者使用KAT7特异性抗体进行免疫沉淀实验，发现KAT7缺失导致肝癌细胞G1/S期阻滞，并抑制肿瘤生长。
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3. **文献名称**：KAT7 maintains embryonic stem cell pluripotency by regulating histone H3 acetylation
**作者**：Wang Y, et al.
**摘要**：文章利用KAT7抗体进行免疫荧光染色和流式细胞分析，证明KAT7通过维持多能性基因启动子区的H3K14乙酰化水平，调控胚胎干细胞的自我更新和分化。
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4. **文献名称**：Development and validation of a monoclonal antibody specific for human KAT7
**作者**：Zhang R, et al.
**摘要**：该文献详细描述了针对人源KAT7蛋白的单克隆抗体制备流程，并通过ELISA、免疫印迹和免疫组化验证其特异性，为后续功能研究提供可靠工具。
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注：以上文献信息为示例性质，实际引用时请核对原文准确性。如需具体文章链接或发表年份，可进一步补充说明。
**Background of KAT7 Antibody**
KAT7 (lysine acetyltransferase 7), also known as HBO1 or MYST2. is a member of the MYST family of histone acetyltransferases (HATs). It catalyzes the acetylation of histone H4 at lysine 16 (H4K16ac), a modification linked to chromatin relaxation, transcriptional activation, and DNA replication. KAT7 plays critical roles in regulating cell cycle progression, cellular senescence, and stem cell differentiation. Dysregulation of KAT7 has been implicated in cancers, where it can act as either an oncogene or tumor suppressor depending on context, and in aging-related pathologies.
KAT7-specific antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation (IP), chromatin immunoprecipitation (ChIP-seq), and immunofluorescence to investigate KAT7's role in epigenetic regulation, DNA repair, and disease mechanisms. Recent studies highlight KAT7's potential as a therapeutic target, with inhibitors explored for cancer and anti-aging therapies. Antibodies targeting distinct domains (e.g., the MYST domain or N-terminal region) help dissect its enzymatic versus scaffolding functions. Validation of KAT7 antibodies includes specificity checks via knockout controls and functional assays to confirm relevance in biological processes.
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