| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Prolyl 4-hydroxylase subunit alpha-1, 4-PH alpha-1, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1, P4HA1, P4HA |
| Entrez GeneID | 5033 |
| WB Predicted band size | 61.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This P4HA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-442 amino acids from the C-terminal region of human P4HA1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KANSL1L抗体的3篇示例文献及其摘要(注：文献为模拟示例，实际引用请核实数据库)：
1. **文献名称**：*KANSL1L as a regulator of histone acetylation in NSL complex-mediated transcription*
**作者**：Smith A, et al.
**摘要**：本研究揭示了KANSL1L在NSL复合体中的功能，通过特异性抗体进行免疫沉淀和Western blot分析，证实其与组蛋白乙酰转移酶MOF的相互作用，调控靶基因的转录激活。
2. **文献名称**：*Dysregulation of KANSL1L in cancer progression and its diagnostic potential*
**作者**：Chen B, et al.
**摘要**：利用KANSL1L抗体对多种癌症组织进行免疫组化分析，发现KANSL1L表达水平与肿瘤侵袭性呈负相关，提示其可能作为癌症预后标志物。
3. **文献名称**：*KANSL1L deficiency alters neuronal gene expression and links to neurodevelopmental disorders*
**作者**：Wang Y, et al.
**摘要**：通过CRISPR敲除结合KANSL1L抗体的染色质免疫沉淀(ChIP)，阐明KANSL1L缺失导致神经元发育相关基因的异常表观遗传调控，可能与自闭症谱系障碍相关。
**提示**：实际文献可能需要通过PubMed/Google Scholar以“KANSL1L antibody”或“KANSL1L function”为关键词检索，并筛选涉及抗体实验(如WB、IF、IP等)的研究。
The KANSL1L antibody is a research tool designed to detect the KANSL1L (KAT8 Regulatory NSL Complex Subunit 1-Like) protein, a paralog of KANSL1 within the NSL (non-specific lethal) complex. This evolutionarily conserved complex regulates histone acetylation, particularly via the histone acetyltransferase KAT8 (lysine acetyltransferase 8), influencing chromatin remodeling and gene expression. KANSL1L shares structural homology with KANSL1 but exhibits distinct expression patterns and functional roles, potentially acting as a regulatory subunit or compensatory factor in specific cellular contexts.
Antibodies targeting KANSL1L are used to study its expression, localization, and interactions in tissues or cell lines, often applied in techniques like Western blotting, immunofluorescence, or co-immunoprecipitation. Research suggests KANSL1L involvement in developmental processes and disease pathways, including neurodevelopmental disorders and cancer, though its precise mechanisms remain under investigation. Studies also explore its role in maintaining genomic stability and regulating transcription.
As a relatively understudied protein, KANSL1L antibodies aid in elucidating its biological significance, particularly in differentiating its functions from KANSL1. Commercial antibodies are typically validated for specificity across human, mouse, or rat samples, with molecular weights around 100-110 kDa. Ongoing research aims to clarify its contributions to epigenetic regulation and potential therapeutic applications.
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