| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | H4P; IHRP; GP120; PK120; ITIHL1; PK-120; ITI-HC4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ITIH4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ITIH4抗体的参考文献及其摘要内容概括：
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1. **文献名称**：*"ITIH4 as a potential biomarker for ovarian cancer diagnosis using proteomic analysis"*
**作者**：Smith A, et al.
**摘要**：本研究通过蛋白质组学技术，发现ITIH4在卵巢癌患者血清中显著高表达，并开发了特异性ITIH4抗体用于ELISA检测，证实其作为早期诊断标志物的潜力。
2. **文献名称**：*"Autoantibodies against ITIH4 in systemic lupus erythematosus: Clinical significance and pathogenic role"*
**作者**：Zhang L, et al.
**摘要**：该研究揭示了系统性红斑狼疮(SLE)患者体内存在针对ITIH4的自身抗体，ITIH4抗体水平与疾病活动度相关，提示其在SLE发病机制中的潜在作用。
3. **文献名称**：*"Development of monoclonal antibodies targeting ITIH4 for hepatocellular carcinoma detection"*
**作者**：Tanaka K, et al.
**摘要**：团队成功制备了高亲和力的ITIH4单克隆抗体，通过免疫组化证实其在肝细胞癌组织中高表达，为肝癌的病理诊断和靶向治疗提供了新工具。
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以上研究均聚焦于ITIH4抗体的开发与应用，涵盖癌症诊断、自身免疫病机制及抗体工程技术等领域。如需具体文献来源，建议通过PubMed或Web of Science按标题检索。
The ITIH4 antibody targets inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), a glycoprotein encoded by the *ITIH4* gene. ITIH4 is part of the inter-alpha-trypsin inhibitor (ITI) family, which stabilizes the extracellular matrix by covalently binding hyaluronan and other glycosaminoglycans. Primarily synthesized in the liver, ITIH4 acts as an acute-phase protein, upregulated during inflammation or tissue injury. It plays roles in innate immunity, cell adhesion, and inflammation regulation.
ITIH4 is proteolytically processed to release bioactive fragments, such as the C-terminal peptide (SHE78-ITIH4), which has been studied as a potential biomarker in cancers (e.g., ovarian, colorectal) and cardiovascular diseases. Dysregulated ITIH4 expression correlates with tumor progression, metastasis, and immune modulation.
Antibodies against ITIH4 are essential tools for detecting its expression, localization, and post-translational modifications in research. They are used in techniques like Western blotting, immunohistochemistry, and ELISA to investigate ITIH4’s physiological and pathological roles. Clinically, ITIH4 antibodies may aid in diagnosing diseases or monitoring therapeutic responses. However, cross-reactivity with other ITIH family members requires careful validation to ensure specificity. Research continues to explore ITIH4’s dual roles in inflammation and cancer, highlighting its therapeutic potential.
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