| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ITGA3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ITGA3抗体的参考文献及其摘要概括：
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1. **"Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis"**
*Authors: Mitchell K, et al.*
*摘要*：研究利用ITGA3抗体阻断实验，揭示α3β1整合素在皮肤肿瘤发生中的作用，发现其通过调控CCN2因子促进肿瘤细胞侵袭。
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2. **"Integrin α3 regulates endosomal recycling to control cell migration and tumor metastasis"**
*Authors: Rainero E, et al.*
*摘要*：通过ITGA3抗体的免疫荧光和流式细胞术，证明ITGA3通过调控内体循环通路影响乳腺癌细胞的迁移和转移能力。
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3. **"Podocyte-specific deletion of integrin α3 results in progressive glomerular disease"**
*Authors: Kreidberg JA, et al.*
*摘要*：使用ITGA3抗体进行肾组织染色，发现足细胞中ITGA3缺失导致肾小球基底膜异常，引发慢性肾脏疾病。
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4. **"Targeting integrin α3 inhibits stemness in lung cancer"**
*Authors: Liu S, et al.*
*摘要*：通过ITGA3抗体阻断实验及Western blot分析，证实靶向ITGA3可抑制肺癌干细胞特性，为治疗提供潜在策略。
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以上文献均聚焦于ITGA3抗体在疾病机制研究中的具体应用，涵盖肿瘤、肾脏疾病等领域。
The ITGA3 antibody targets integrin alpha-3 (ITGA3), a subunit of the α3β1 integrin heterodimer, a cell surface receptor critical for cell-matrix adhesion and signaling. Integrins are transmembrane proteins composed of α and β subunits that mediate interactions between cells and the extracellular matrix (ECM), regulating processes like cell migration, proliferation, and survival. ITGA3 pairs with β1 (ITGB1) to form α3β1. which binds laminin, fibronectin, and other ECM components, playing roles in tissue development, wound healing, and epithelial cell function.
ITGA3 is expressed in various tissues, including kidney, lung, skin, and endothelial cells. Dysregulation of ITGA3 is linked to pathologies such as cancer metastasis, kidney fibrosis, and inflammatory skin disorders. In cancer, elevated ITGA3 may promote tumor invasion by facilitating ECM remodeling and cell motility. Antibodies against ITGA3 are used in research to study its expression, localization, and functional roles. They also serve as tools to block α3β1 activity in vitro or in vivo, helping elucidate its contribution to disease mechanisms.
Commercial ITGA3 antibodies are available for techniques like Western blot, immunohistochemistry, and flow cytometry. Validation of specificity is crucial due to potential cross-reactivity with other integrin subunits. Recent studies explore therapeutic applications, such as targeting ITGA3 to inhibit tumor progression or fibrosis, highlighting its clinical relevance.
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