Rabbit Polyclonal INSC Antibody

The INSC antibody is associated with the study of the Inscuteable (INSC) protein, a key regulator of asymmetric cell division in developing tissues. Initially identified in *Drosophila* neuroblasts, INSC plays a critical role in orienting the mitotic spindle and ensuring proper cell fate determination during neural development. In mammals, INSC homologs are implicated in processes like neurogenesis, planar cell polarity, and tissue morphogenesis. Antibodies targeting INSC are essential tools for investigating these mechanisms, enabling researchers to visualize protein localization, assess expression levels, and dissect molecular pathways in model organisms and cell cultures. Dysregulation of INSC has been linked to developmental disorders and cancers, particularly in contexts where asymmetric division is disrupted. For instance, INSC overexpression in certain tumors may correlate with stem-like properties or therapy resistance. The antibody’s utility spans immunohistochemistry, Western blotting, and fluorescence microscopy, aiding both basic research and translational studies. Recent interest in INSC also extends to regenerative medicine, given its role in progenitor cell maintenance. Despite progress, challenges remain in fully elucidating its interactome and context-specific functions. Overall, INSC antibodies serve as vital reagents for decoding cellular polarity mechanisms and their implications in health and disease.