Rabbit Polyclonal IP6K2 Antibody

IP6K2 (inositol hexakisphosphate kinase 2) is an enzyme that belongs to the inositol phosphate kinase family, primarily catalyzing the conversion of inositol hexakisphosphate (IP6) to 5-diphosphoinositol pentakisphosphate (5-IP7). This metabolite plays a critical role in cellular processes such as apoptosis, metabolic regulation, and vesicular trafficking. IP6K2 antibodies are essential tools for studying the expression, localization, and functional mechanisms of IP6K2 in various biological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect endogenous or overexpressed IP6K2 in cell lines, tissues, or experimental models. Research has linked IP6K2 to cancer progression, insulin signaling, and neurological disorders, making its antibody particularly valuable in disease-related studies. For instance, IP6K2 overexpression is associated with tumor growth and chemoresistance, while its inhibition has shown potential therapeutic effects in metabolic syndromes. Commercially available IP6K2 antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Researchers should consider epitope regions, host species (e.g., rabbit, mouse), and clonality (monoclonal vs. polyclonal) when selecting antibodies for specific applications. Proper validation and optimization remain crucial due to potential cross-reactivity with other IP6K family members (IP6K1/IP6K3) or structurally similar proteins.