| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LGN; CMCS; PINS; DFNB82 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GPSM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GPSM2抗体的3篇代表性文献的示例(注：部分内容基于真实研究概括，文献标题和作者为虚构示例，实际引用请核实原始论文)：
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1. **标题**：GPSM2调控细胞极性分裂的分子机制研究
**作者**：Smith A, et al.
**摘要**：本研究通过免疫荧光和基因沉默技术，揭示GPSM2蛋白在哺乳动物细胞不对称分裂中的关键作用。抗GPSM2抗体用于定位其与Gαi蛋白复合物的相互作用，证明其在纺锤体定向调控中的功能异常可导致细胞极性紊乱。
2. **标题**：GPSM2基因突变导致先天性耳聋的功能验证
**作者**：Wang X, et al.
**摘要**：通过构建GPSM2敲除小鼠模型，结合抗GPSM2抗体的Western blot分析，发现GPSM2缺失导致耳蜗毛细胞发育缺陷。研究证实该蛋白在内耳细胞极性与纤毛形成中不可或缺，为遗传性耳聋提供了分子机制解释。
3. **标题**：GPSM2抗体在癌症研究中的临床应用潜力
**作者**：Lee JH, et al.
**摘要**：利用特异性抗GPSM2抗体检测多种肿瘤样本，发现GPSM2在乳腺癌和结直肠癌中高表达，并与转移风险相关。研究提示GPSM2可能成为预后标志物及靶向治疗的新靶点。
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**提示**：实际研究中建议通过PubMed或Web of Science以“GPSM2 antibody”或“GPSM2 function”为关键词检索最新文献，重点关注其与细胞极性、发育疾病或肿瘤相关的机制研究。
GPSM2 (G Protein Signaling Modulator 2), also known as AGS3 or LGN, is a regulatory protein involved in G protein-coupled signaling pathways. It belongs to the GoLoco motif-containing protein family, which modulates heterotrimeric G-protein activity by binding to Gαi subunits, stabilizing their GDP-bound inactive state. GPSM2 plays a critical role in cell division, particularly during asymmetric cell division and spindle orientation, by interacting with NuMA (nuclear mitotic apparatus protein) and other polarity regulators. This function is essential for tissue development, neurogenesis, and planar cell polarity.
Antibodies targeting GPSM2 are widely used in research to investigate its localization, expression dynamics, and molecular interactions during mitosis and cellular polarization. They are critical tools for studying developmental biology, cancer (where spindle misorientation may contribute to tumorigenesis), and neurological disorders linked to GPSM2 dysfunction. Commercial GPSM2 antibodies are typically validated for applications like Western blotting, immunofluorescence, and immunoprecipitation. Mutations in the GPSM2 gene are associated with human pathologies, including Chudley-McCullough syndrome (a rare autosomal recessive disorder characterized by hearing loss and brain malformations), underscoring its biomedical relevance.
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