Rabbit Polyclonal GPR89A/GPR89B Antibody

GPR89A (Golgi pH Regulator) and GPR89B are paralogous proteins belonging to the G protein-coupled receptor (GPCR) superfamily, though their exact functional roles remain unclear. Predominantly localized to the Golgi apparatus, they are implicated in maintaining Golgi luminal pH homeostasis and glycosylation processes. GPR89A is ubiquitously expressed, while GPR89B shows tissue-specific expression, particularly in the brain and gastrointestinal tract. Structurally, they feature multiple transmembrane domains but lack classical GPCR signaling motifs, suggesting atypical mechanisms. Antibodies targeting GPR89A/GPR89B are critical tools for investigating their subcellular distribution, expression patterns, and interactions. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to elucidate their roles in Golgi dysfunction-linked pathologies, such as cancer, neurodegenerative diseases, and metabolic disorders. Recent studies propose GPR89A as a potential biomarker in certain cancers, while GPR89B may influence neurotransmitter regulation. However, challenges persist due to sequence homology between the paralogs, requiring antibody validation via knockout controls. Ongoing research aims to clarify their physiological ligands and downstream signaling, which could unlock therapeutic targeting opportunities for Golgi-associated diseases.