Rabbit Polyclonal GPR162 Antibody

GPR162 (G protein-coupled receptor 162) is an orphan receptor belonging to the class A G protein-coupled receptor (GPCR) family. Its physiological function and endogenous ligands remain poorly characterized, though it is predominantly expressed in the brain, particularly in regions like the hypothalamus, suggesting potential roles in neuroregulation, energy homeostasis, or neurotransmitter signaling. GPR162 antibodies are essential tools for studying its expression patterns, subcellular localization, and interactions. These antibodies are typically developed using immunogenic peptides derived from conserved regions of the human GPR162 protein and validated for specificity via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Research has linked GPR162 to metabolic disorders and neurological conditions, with some studies implicating it in β-cell function and insulin secretion. However, its orphan status and limited functional data pose challenges in defining its exact biological pathways. Commercially available GPR162 antibodies enable investigations into tissue distribution, protein-protein interactions, and potential therapeutic targets. Recent advances in GPCR structural biology may further clarify GPR162's role, aiding the development of targeted therapies. Researchers using these antibodies should account for species reactivity and cross-reactivity risks, often mitigated through knockout validation controls.