Rabbit Polyclonal ADGRA1 Antibody

ADGRA1 (Adhesion G Protein-Coupled Receptor A1), also known as GPR123. is a member of the adhesion GPCR family characterized by a large extracellular region containing adhesion-related domains. These receptors are implicated in cell-cell and cell-matrix interactions, though ADGRA1’s precise biological functions remain poorly understood. It is highly expressed in the central nervous system, suggesting potential roles in neural development or maintenance, and has been detected in other tissues like the heart and kidneys. ADGRA1 antibodies are essential tools for studying its localization, expression patterns, and molecular interactions. These antibodies, typically raised in rabbits or mice, are validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Recent studies link ADGRA1 to cancer progression, angiogenesis, and neurological disorders, though mechanistic insights are limited. Researchers rely on high-specificity antibodies to explore ADGRA1’s structure (e.g., its seven-transmembrane topology and GPS proteolytic site) and signaling pathways, which may involve G proteins or non-canonical cascades. Challenges include distinguishing ADGRA1 from homologous receptors and confirming antibody specificity via knockout controls. Ongoing work aims to clarify its physiological ligands and therapeutic potential in diseases.