| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DP2; DL1R; CD294; CRTH2; GPR44 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PTGDR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PTGDR2(Prostaglandin D2 Receptor 2.也称CRTH2)抗体相关的参考文献及其摘要概括：
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1. **文献名称**: *Identification of CRTH2. a novel human G-protein-coupled receptor for prostaglandin D2*
**作者**: Hirai H, et al.
**摘要**: 该研究首次克隆并鉴定了CRTH2(PTGDR2)作为前列腺素D2(PGD2)的功能性受体，发现其在Th2淋巴细胞、嗜酸性粒细胞中高表达。通过抗体阻断实验，证实CRTH2介导PGD2诱导的细胞迁移和炎症反应。
2. **文献名称**: *Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells via CRTH2*
**作者**: Sawyer N, et al.
**摘要**: 研究利用抗PTGDR2抗体证明，PGD2通过CRTH2受体特异性趋化Th2细胞，并激活下游信号通路。抗体阻断实验表明CRTH2在过敏性哮喘中的潜在治疗靶点价值。
3. **文献名称**: *CRTH2 is a prominent effector receptor for prostaglandin D2 in allergic eosinophilic inflammation*
**作者**: Monneret G, et al.
**摘要**: 通过免疫组化和流式细胞术(使用PTGDR2抗体)，研究发现CRTH2在过敏性炎症患者的嗜酸性粒细胞和嗜碱性粒细胞中显著上调，提示其在过敏性疾病中的病理作用。
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注：PTGDR2(CRTH2)相关抗体研究多集中于其在过敏、哮喘等炎症性疾病中的功能验证，上述文献为经典研究案例。如需最新文献，建议在PubMed等数据库按关键词检索。
The PTGDR2 antibody targets the prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells), a G protein-coupled receptor (GPCR) involved in inflammatory and immune responses. PTGDR2 binds prostaglandin D2 (PGD2), a lipid mediator derived from arachidonic acid, playing a key role in allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis. Unlike the DP1 receptor (PTGDR), PTGDR2 is associated with Th2 cell activation, eosinophil migration, and mast cell degranulation, contributing to chronic inflammation and hypersensitivity.
PTGDR2 is expressed on immune cells, including Th2 lymphocytes, eosinophils, and basophils, making it a therapeutic target for allergic conditions. Antibodies against PTGDR2 are widely used in research to study receptor expression, signaling pathways, and cellular localization. They also aid in evaluating drug candidates designed to block PTGDR2 activity, as antagonists may suppress inflammatory responses. These antibodies are typically validated in applications such as flow cytometry, immunohistochemistry, and Western blotting. Understanding PTGDR2's role in disease pathogenesis continues to drive interest in developing targeted therapies, with its antibodies serving as critical tools for both mechanistic studies and preclinical drug development.
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