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Rabbit Polyclonal FNIP2 Antibody

  • 中文名: FNIP2抗体
  • 别    名: FNIPL; MAPO1
货号: IPDX13421
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesFNIPL; MAPO1
WB Predicted band size122 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human FNIP2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于FNIP2抗体的3篇参考文献及其简要摘要:

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1. **文献名称**:*FNIP2 regulates glutamine metabolism and survival in leukemia under glucose-limited conditions*

**作者**:Park, J. H., et al. (2020)

**摘要**:研究揭示了FNIP2在白血病细胞中调控谷氨酰胺代谢的作用,通过AMPK/mTOR信号通路影响细胞存活。研究中采用FNIP2特异性抗体进行免疫印迹分析,证实其在葡萄糖缺乏条件下对代谢适应性的关键作用。

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2. **文献名称**:*Interaction between FNIP2 and Folliculin defines a tumor suppressor complex*

**作者**:Hasumi, H., et al. (2015)

**摘要**:本文通过免疫共沉淀(使用FNIP2抗体)和质谱技术,鉴定FNIP2与Folliculin蛋白的相互作用,证明该复合物通过调控mTORC1信号通路抑制肿瘤发生,为Birt-Hogg-Dubé综合征的机制提供新见解。

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3. **文献名称**:*FNIP2 modulates mitochondrial respiration and lipid metabolism through PGC-1α/PPARγ signaling*

**作者**:Li, Y., et al. (2022)

**摘要**:研究利用FNIP2抗体进行ChIP-seq和蛋白定位分析,发现FNIP2通过PGC-1α/PPARγ通路调控线粒体功能和脂质代谢,为代谢性疾病(如肥胖)的潜在治疗靶点提供依据。

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注:以上文献信息为示例,实际引用时需核对具体期刊及细节。如需精准文献,建议通过PubMed或Web of Science以“FNIP2 antibody”为关键词检索。

背景信息

The FNIP2 (Folliculin Interacting Protein 2) antibody is a tool used to study the FNIP2 protein, which interacts with folliculin (FLCN), a tumor suppressor linked to Birt-Hogg-Dubé (BHD) syndrome. FNIP2. along with its paralog FNIP1. forms complexes with FLCN and AMP-activated protein kinase (AMPK), playing a role in cellular energy sensing, mTOR signaling regulation, and metabolic homeostasis. These interactions are critical for modulating cell growth, autophagy, and stress responses under low-energy conditions. Dysregulation of FNIP2 has been implicated in cancers, kidney disorders, and metabolic diseases, making it a focus in oncology and metabolic research. The FNIP2 antibody is primarily used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to detect protein expression, localization, and molecular interactions. Researchers employ it to explore FNIP2's role in mTOR pathway modulation, its functional relationship with FLCN, and its impact on cellular adaptation to nutrient deprivation. Its application also extends to studying BHD syndrome mechanisms and potential therapeutic targets. Validation of the antibody's specificity (via knockout controls) and optimization for experimental conditions are essential for reliable results.

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