| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C1orf188 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human RNF207 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与RNF207抗体相关的研究文献概览(虚拟数据供参考)：
1. **文献名称**: RNF207 regulates cardiac ion channel stability through ubiquitination
**作者**: Zhang L, et al. (2018)
**摘要**: 本研究利用RNF207特异性抗体进行免疫沉淀实验，发现RNF207通过泛素化修饰调控心脏钾离子通道蛋白hERG的稳定性，为心律失常机制提供新见解。
2. **文献名称**: RNF207 deficiency exacerbates high-fat diet-induced metabolic syndrome in mice
**作者**: Kim S, et al. (2020)
**摘要**: 通过Western blot和免疫组化技术结合RNF207抗体，证实敲除RNF207的小鼠在代谢应激下脂肪组织炎症反应增强，提示其参与能量代谢调控通路。
3. **文献名称**: Proteomic analysis of RNF207-interacting proteins in hepatocellular carcinoma
**作者**: Wang Y, et al. (2021)
**摘要**: 使用RNF207抗体进行免疫共沉淀联合质谱分析，筛选出肝癌细胞中与RNF207相互作用的E3泛素连接酶网络，揭示其潜在肿瘤抑制功能。
*注：以上为模拟文献示例，实际研究中建议通过PubMed/Google Scholar以"RNF207 antibody"为关键词检索最新实验性研究论文。*
The RNF207 antibody is a research tool designed to detect and study the Ring Finger Protein 207 (RNF207), an E3 ubiquitin ligase involved in protein ubiquitination and degradation. RNF207 plays a critical role in regulating cardiac function, particularly in maintaining ion channel stability and electrical activity in cardiomyocytes. It has been implicated in cardiac arrhythmias, such as Brugada syndrome, by modulating the degradation of proteins like SCN5A-encoded Nav1.5 sodium channels. Dysregulation of RNF207 is also associated with heart failure and metabolic disorders, highlighting its importance in cardiovascular health.
The antibody, typically generated in hosts like rabbits or mice, enables the detection of RNF207 in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It aids in elucidating RNF207's expression patterns, subcellular localization, and interactions with other proteins. Researchers utilize this tool to explore its role in ubiquitin-mediated proteolysis, cardiac pathophysiology, and potential therapeutic targets. Commercial RNF207 antibodies are often validated for specificity and sensitivity, targeting specific epitopes or post-translational modifications. As a molecular probe, it contributes to advancing understanding of cellular protein quality control mechanisms and disease mechanisms linked to RNF207 dysfunction.
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