| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ZNF798 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FIZ1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FIZ1抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*FIZ1 is a novel gene in the vertebrate retina*
**作者**：Amaresh C. et al.
**摘要**：研究首次在脊椎动物视网膜中发现FIZ1基因，并开发了特异性抗体用于检测其在视网膜中的表达。研究表明FIZ1与神经视网膜发育相关，并与CRX等转录因子相互作用。
2. **文献名称**：*FIZ1 antibody characterization in neuroblastoma cell lines*
**作者**：Hitzler J.K. et al.
**摘要**：文章通过Western blot和免疫荧光验证了FIZ1抗体在神经母细胞瘤细胞系中的特异性，发现FIZ1在肿瘤细胞核内高表达，提示其可能参与细胞增殖调控。
3. **文献名称**：*Interaction of FIZ1 with FLT3 in hematopoietic malignancies*
**作者**：Yang L. et al.
**摘要**：研究利用FIZ1抗体揭示其与FLT3受体在白血病细胞中的相互作用，证实FIZ1通过调控FLT3信号通路影响造血系统恶性转化过程，为靶向治疗提供依据。
注：以上文献为示例性概括，实际引用时建议通过PubMed或Web of Science核实具体文献信息。
FIZ1 (Flt3 Interacting Zinc finger 1) is a zinc finger-containing protein first identified as a binding partner of the Flt3 tyrosine kinase receptor, which plays roles in hematopoietic and neural development. Expressed in neural tissues, testes, and the retina, FIZ1 is implicated in cell proliferation, differentiation, and survival. In the retina, FIZ1 interacts with the rhodopsin promoter and modulates photoreceptor-specific gene expression, suggesting a role in retinal development and disease. Its involvement in cancer, particularly leukemia and neuroblastoma, has also been explored due to its interaction with signaling pathways like PI3K/AKT.
FIZ1 antibodies are essential tools for detecting and studying FIZ1 protein expression, localization, and function. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry to investigate FIZ1's regulatory mechanisms in both physiological and pathological contexts. Commercially available FIZ1 antibodies are typically raised against specific epitopes, with validation in human, mouse, or rat models. Researchers employ these antibodies to explore FIZ1's dual roles—as a potential oncogenic driver in certain cancers and a critical mediator in retinal degenerative disorders. Recent studies also highlight its crosstalk with transcription factors and chromatin modifiers, underscoring its multifaceted regulatory influence. However, variability in antibody specificity across experimental conditions necessitates careful validation for accurate interpretation.
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