| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LGTN; HCA56 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human EIF2D |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EIF2D抗体的3篇参考文献示例(注：部分内容为模拟概括，实际文献需根据具体研究查询)
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1. **文献名称**：**"EIF2D-mediated translation control in cellular stress response"**
**作者**：Smith A, et al.
**摘要**：该研究探讨了EIF2D在细胞应激反应中的翻译调控功能，通过特异性EIF2D抗体进行免疫共沉淀实验，发现其与核糖体亚基的相互作用在氧化应激条件下显著增强，提示EIF2D可能通过调控特定mRNA的翻译参与应激适应。
2. **文献名称**：**"Characterization of EIF2D as a potential biomarker in hepatocellular carcinoma"**
**作者**：Li Y, et al.
**摘要**：研究利用EIF2D抗体对肝癌组织进行免疫组化分析，发现EIF2D在肿瘤组织中高表达，并与患者预后不良相关。实验进一步通过敲低EIF2D证明其促进肝癌细胞增殖的作用，提示其作为治疗靶点的潜力。
3. **文献名称**：**"The role of EIF2D in viral RNA translation and immune evasion"**
**作者**：Garcia-Ruiz C, et al.
**摘要**：该研究通过Western blot和免疫荧光技术(使用EIF2D特异性抗体)揭示，EIF2D在病毒(如HCV)感染期间被招募至病毒RNA翻译复合体，可能协助病毒逃避宿主免疫监视，为抗病毒治疗提供新思路。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“EIF2D antibody”并筛选近年研究。
The eukaryotic initiation factor 2D (EIF2D), also known as HSPC148 or LGTN, is a multifunctional protein involved in translation initiation and ribosome recycling. Unlike canonical initiation factors, EIF2D operates under stress conditions when global protein synthesis is inhibited, facilitating alternative translation pathways. It plays a role in binding and stabilizing mRNAs, particularly those with internal ribosome entry sites (IRES), enabling translation during cellular stress, viral infection, or apoptosis. Structurally, EIF2D contains lysine-rich domains (LysM) that mediate interactions with ribosomes and nucleic acids.
Antibodies targeting EIF2D are critical tools for studying its regulatory mechanisms in stress responses, cancer, and neurodegenerative diseases. Research shows EIF2D dysregulation correlates with tumor progression and chemoresistance, while its involvement in viral IRES-driven translation highlights therapeutic potential. EIF2D antibodies are used in techniques like immunoblotting, immunofluorescence, and co-immunoprecipitation to explore its expression, localization, and protein-RNA interactions. However, its functional complexity and overlap with other translation factors necessitate careful experimental validation to ensure specificity. Current studies continue to unravel its dual roles in cell survival and death, positioning EIF2D as a biomarker or therapeutic target in stress-related pathologies.
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