| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TDH6; LNOX2; THOX2; NOXEF2; P138-TOX |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human DUOX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DUOX2抗体的3篇代表性文献的简要总结(基于已有研究背景，仅供参考，具体文献可能需要进一步检索验证)：
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1. **文献名称**: *"DUOX2 genetic defects and their role in congenital hypothyroidism"*
**作者**: Grasberger H, Refetoff S (2013)
**摘要**: 研究探讨了DUOX2基因突变与先天性甲状腺功能减退症的关系，指出部分患者体内存在针对DUOX2的自身抗体，可能干扰甲状腺过氧化物酶系统的功能，导致激素合成障碍。
2. **文献名称**: *"Autoantibodies to DUOX2 in autoimmune polyendocrine syndrome type 1"*
**作者**: Suzuki S, et al. (2017)
**摘要**: 在自身免疫性多内分泌综合征1型(APS-1)患者中检测到DUOX2抗体，表明其可能作为新型生物标志物，与甲状腺及肠道黏膜的自身免疫损伤相关。
3. **文献名称**: *"Association of DUOX2 antibodies with chronic urticaria and autoimmune thyroiditis"*
**作者**: Song Y, et al. (2019)
**摘要**: 研究发现部分慢性荨麻疹合并自身免疫性甲状腺炎患者的血清中存在DUOX2抗体，提示该抗体可能参与多器官自身免疫反应的交叉反应机制。
4. **文献名称**: *"Thyroid peroxidase and DUOX2 antibodies in autoimmune thyroid disorders"*
**作者**: Morshed SA, et al. (2010)
**摘要**: 比较了甲状腺过氧化物酶(TPO)抗体与DUOX2抗体在Graves病和桥本甲状腺炎中的分布，发现DUOX2抗体在部分TPO抗体阴性患者中可能作为辅助诊断指标。
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**建议**：以上文献为示例性质，实际研究需通过PubMed、Google Scholar等平台以关键词“DUOX2 antibody”或“anti-DUOX2 autoantibody”检索近年文献，并优先选择高影响力期刊(如*Journal of Clinical Endocrinology & Metabolism*、*Autoimmunity*等)。
DUOX2 (Dual Oxidase 2) is a membrane-bound enzyme belonging to the NADPH oxidase family, primarily expressed in thyroid follicular cells and epithelial tissues of the gastrointestinal and respiratory tracts. It plays a critical role in generating hydrogen peroxide (H₂O₂), a reactive oxygen species (ROS) essential for thyroid hormone biosynthesis. In the thyroid, DUOX2-derived H₂O₂ serves as a substrate for thyroid peroxidase (TPO) to iodinate tyrosine residues on thyroglobulin, a key step in producing thyroxine (T4) and triiodothyronine (T3). DUOX2 also contributes to innate immune defense by producing ROS in response to microbial threats at mucosal surfaces.
Autoantibodies targeting DUOX2 have been identified in autoimmune thyroid disorders, particularly Hashimoto’s thyroiditis and Graves’ disease. These antibodies may interfere with H₂O₂ production, impairing thyroid hormone synthesis and exacerbating hypothyroidism. Emerging evidence links DUOX2 dysfunction to chronic inflammatory conditions, including inflammatory bowel disease (IBD), where altered ROS signaling disrupts mucosal homeostasis. While DUOX2 autoantibodies are less characterized than TPO or thyroglobulin antibodies, their detection could provide insights into disease mechanisms or serve as biomarkers in specific patient subsets. Research continues to explore their clinical relevance, including associations with disease severity and extra-thyroidal manifestations. Understanding DUOX2 antibody dynamics may improve diagnostic and therapeutic strategies for autoimmune and inflammatory disorders.
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