| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DPCD |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DPCD抗体的3篇示例文献(注：文献为示例性质，具体内容需根据实际研究调整)：
1. **文献名称**: "Characterization of DPCD as a Novel Ciliary Protein Involved in Primary Ciliary Dyskinesia"
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫荧光和Western blot技术，验证了DPCD抗体在人类呼吸道上皮细胞中的特异性表达，发现DPCD蛋白缺失与纤毛运动功能障碍相关，为原发性纤毛运动障碍(PCD)的分子机制提供了新证据。
2. **文献名称**: "Development of a Monoclonal Antibody Targeting DPCD for Diagnostic Applications"
**作者**: Chen L, et al.
**摘要**: 文章报道了一种高特异性的DPCD单克隆抗体的开发，该抗体能够通过免疫组化检测石蜡包埋组织中DPCD的表达水平，并初步应用于PCD患者的临床样本筛查，显示其在诊断中的潜在价值。
3. **文献名称**: "DPKD and DPCD: Functional Redundancy in Renal Cilia Signaling Pathways"
**作者**: Gupta R, et al.
**摘要**: 研究利用DPCD抗体在小鼠模型中揭示了DPCD与DPKD(多囊肾病相关蛋白)在肾小管纤毛信号通路中的协同作用，表明两者在维持细胞稳态中具有重叠功能。
4. **文献名称**: "Antibody-Based Profiling of DPCD in Cancer Cell Lines"
**作者**: Wang Y, et al.
**摘要**: 通过高通量筛选多种DPCD抗体，研究发现该蛋白在特定癌症细胞系中异常高表达，提示其可能作为肿瘤生物标志物，并探讨了其在癌细胞迁移中的作用机制。
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**注意**：以上文献信息为模拟示例，实际研究中需根据具体需求检索PubMed、Web of Science等数据库获取真实文献。DPCD相关研究目前可能较少，建议结合“原发性纤毛运动障碍”“抗体应用”等关键词扩展搜索。
**Background of DPCD Antibody**
DPCD (Deleted in Primary Ciliary Dyskinesia) is a protein implicated in the pathogenesis of primary ciliary dyskinesia (PCD), a rare genetic disorder characterized by defective cilia function, leading to chronic respiratory infections, infertility, and situs abnormalities. The DPCD gene, located on chromosome 10 in humans, was initially identified through studies linking its deletion to PCD-related ciliary defects.
DPCD antibodies are immunological tools developed to detect and study the DPCD protein's expression, localization, and functional role in cellular processes. Research suggests DPCD may participate in ciliogenesis, cilia maintenance, or intracellular signaling, though its precise mechanisms remain under investigation. Antibodies against DPCD enable visualization and quantification of the protein in tissues and cell cultures, aiding in elucidating its contribution to ciliary dysfunction in PCD.
These antibodies are critical in both basic and clinical research. They help validate DPCD's interaction with other ciliary proteins, assess its expression levels in disease models, and explore potential therapeutic targets. Additionally, DPCD antibodies may assist in diagnostic approaches for PCD, particularly in cases where genetic mutations in DPCD are suspected. Current studies continue to refine their specificity and applications, underscoring their importance in advancing understanding of ciliopathies and developing targeted interventions.
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