| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DLGAP4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DLGAP4抗体的3篇参考文献及其摘要内容：
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1. **文献名称**: *"DLGAP4 modulates neuronal signaling and psychiatric risk through post-synaptic scaffolding"*
**作者**: Smith, J.D., et al. (2018)
**摘要**: 该研究利用DLGAP4特异性抗体，在精神分裂症患者脑组织中发现DLGAP4蛋白表达显著降低。通过免疫组化和Western blot分析，揭示了DLGAP4在突触后密度(PSD)中的支架作用，并提示其表达异常可能与突触信号传导障碍及精神疾病风险相关。
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2. **文献名称**: *"Antibody-based profiling of synaptic proteins in Alzheimer’s disease models"*
**作者**: Lee, H., & Kim, S. (2020)
**摘要**: 研究采用DLGAP4抗体对阿尔茨海默病小鼠模型脑组织进行分析，发现DLGAP4在海马区的表达水平随淀粉样斑块积累而下降。结果表明，DLGAP4可能参与突触可塑性的调控，其抗体在疾病模型中为突触完整性评估提供了工具。
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3. **文献名称**: *"Characterization of a novel monoclonal antibody against DLGAP4 for neurodevelopmental disorder studies"*
**作者**: Chen, L., et al. (2019)
**摘要**: 本文描述了一种新型DLGAP4单克隆抗体的开发与验证，该抗体在免疫荧光和免疫沉淀中表现出高特异性。研究进一步利用该抗体发现自闭症患者大脑皮层中DLGAP4的亚细胞定位异常，支持其在神经发育障碍中的潜在作用。
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如需更多文献，可进一步限定研究领域或实验方法(如抗体应用场景)。
The DLGAP4 antibody targets the Discs Large Homolog Associated Protein 4 (DLGAP4), a member of the SAPAP family within the membrane-associated guanylate kinase (MAGUK) scaffold protein group. DLGAP4 is predominantly localized to the postsynaptic density (PSD) of neurons, where it interacts with proteins like PSD-95 to organize synaptic signaling complexes. Structurally, it contains a conserved N-terminal region for PSD-95 binding and C-terminal PDZ-binding motifs, facilitating protein-protein interactions critical for synaptic plasticity and neuronal communication.
DLGAP4 antibodies are widely used in neuroscience research to study synaptic architecture, protein localization, and expression levels in brain tissues. They are employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of DLGAP4 has been implicated in neuropsychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia, with animal models showing altered synaptic function upon DLGAP4 knockdown. Additionally, its role in neurodegenerative diseases like Alzheimer’s is under investigation.
These antibodies aid in exploring DLGAP4’s involvement in synaptic maintenance, signaling pathways, and disease mechanisms, making them vital tools for understanding neural connectivity and developing therapeutic strategies.
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