Rabbit Polyclonal ALX4 Antibody

The ALX4 (Aristaless-like homeobox 4) antibody is a tool used to detect the ALX4 protein, a transcription factor critical in embryonic development and tissue patterning. ALX4 belongs to the paired-class homeodomain protein family, playing roles in craniofacial formation, limb development, and hair follicle regeneration by regulating gene expression. It is expressed in mesenchymal cells and epithelial-mesenchymal interfaces during embryogenesis. Dysregulation of ALX4 has been linked to congenital disorders like frontonasal dysplasia and parietal foramina, as well as cancers (e.g., osteosarcoma, breast cancer), where it may act as a tumor suppressor or oncogene depending on context. The antibody, typically raised in rabbits or mice, enables research applications such as Western blotting, immunohistochemistry, and immunofluorescence to study ALX4's spatial-temporal expression, interactions, and mechanisms in development/disease. Commercial ALX4 antibodies are often validated for specificity against conserved epitopes across human, mouse, and rat homologs. Its utility spans basic developmental biology and clinical research, particularly in understanding skeletal malformations and cancer pathways.