| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/1000 | Human,Mouse,Rat |
| Aliases | CPC8; CYPIIC8; MP-12/MP-20 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CYP2C8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CYP2C8抗体的3篇参考文献示例(注：文献信息为模拟示例，需通过学术数据库核实真实性和原文)：
1. **标题**: *"Development and characterization of a monoclonal antibody specific for human CYP2C8"*
**作者**: Oscarsson S, et al.
**摘要**: 该研究报道了一种针对人CYP2C8酶的高特异性单克隆抗体的开发与验证，通过免疫印迹(Western blot)和免疫组化(IHC)证实其在肝组织及重组蛋白中的特异性识别能力，为CYP2C8表达分析提供可靠工具。
2. **标题**: *"Role of CYP2C8 in drug metabolism: Insights from antibody-based inhibition studies"*
**作者**: Zanger UM, et al.
**摘要**: 研究利用CYP2C8抗体探究该酶在药物代谢中的作用，发现其对抗疟药物(如氯喹)和化疗药物(如紫杉醇)的代谢具有关键影响，抗体阻断实验进一步验证了CYP2C8的底物特异性。
3. **标题**: *"Tissue-specific expression profiling of CYP2C8 using immunohistochemistry: Implications for drug toxicity"*
**作者**: Rodriguez-Antona C, et al.
**摘要**: 通过CYP2C8抗体分析多个人体组织(肝、肾、肠)中该酶的分布，揭示其在肝脏高表达的特点，并探讨了药物代谢差异与CYP2C8表达水平的相关性，为个体化用药提供依据。
**建议**：通过PubMed或Google Scholar搜索关键词“CYP2C8 antibody”、“CYP2C8 characterization”获取最新文献。实际研究中，抗体相关文献多集中于开发、验证或应用方向。
The CYP2C8 antibody is a critical tool for studying the cytochrome P450 2C8 enzyme, a member of the CYP450 superfamily involved in metabolizing endogenous and exogenous compounds. CYP2C8. primarily expressed in the liver and intestine, plays a key role in drug metabolism (e.g., paclitaxel, repaglinide) and the processing of endogenous molecules like arachidonic acid. Genetic polymorphisms in CYP2C8 can influence drug efficacy and toxicity, driving research into its functional variability.
CYP2C8 antibodies are designed to detect and quantify the enzyme in various experimental setups, including Western blotting, immunohistochemistry, and ELISA. These antibodies, often polyclonal or monoclonal, target specific epitopes to ensure specificity, validated through techniques like knockout cell lines or enzymatic inhibition assays. Their applications span drug development, pharmacogenomics, and clinical research, particularly in assessing how genetic variants or drug interactions alter CYP2C8 activity.
In drug discovery, CYP2C8 antibodies help evaluate candidate compounds’ potential to inhibit or induce the enzyme, predicting metabolic interactions. Additionally, they aid in exploring CYP2C8’s role in diseases, such as cancer or metabolic disorders, where its expression may be dysregulated. Reliable CYP2C8 antibodies are thus vital for advancing personalized medicine and understanding complex metabolic pathways.
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