| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FFDD4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CYP26C1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CYP26C1抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **"Selective recognition of CYP26C1 by a monoclonal antibody for retinoic acid metabolism studies"**
*Authors: Tanaka, K., et al.*
**摘要**：本研究开发了一种针对人CYP26C1蛋白的单克隆抗体，通过重组蛋白免疫小鼠获得。抗体特异性经Western blot和免疫荧光验证，成功用于检测细胞系中CYP26C1的表达，揭示了其在视黄酸代谢中的组织特异性调控。
2. **"Characterization of CYP26C1 antibody in developmental models: Insights from zebrafish"**
*Authors: Hernandez, R.E., & Lin, S.*
**摘要**：利用斑马鱼模型验证了一种多克隆CYP26C1抗体的特异性，发现其可标记胚胎发育特定阶段的视黄酸降解活性区域，支持CYP26C1在神经系统发育中的时空表达调控假说。
3. **"CYP26C1 expression in human keratinocytes: Validation of a novel polyclonal antibody"**
*Authors: Müller, J., et al.*
**摘要**：报道了一种兔源多克隆抗体的开发，通过免疫组化和免疫印迹证实CYP26C1在皮肤角质细胞中的表达，并发现其在银屑病组织中表达上调，提示其参与病理性视黄酸失衡。
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注：以上文献为示例性质，实际引用需根据具体研究核实标题与作者信息。建议通过PubMed或Google Scholar以关键词“CYP26C1 antibody”+“validation”/“application”进一步检索最新文献。
The CYP26C1 antibody is a research tool designed to detect and study the cytochrome P450 family 26 subfamily C member 1 (CYP26C1), an enzyme critical in metabolizing retinoic acid (RA), a derivative of vitamin A. CYP26C1. part of the CYP26 enzyme family, regulates RA levels by catalyzing its oxidation into inactive metabolites, ensuring precise spatial and temporal control of RA signaling. This signaling pathway is vital for embryonic development, cellular differentiation, and tissue homeostasis. Dysregulation of CYP26C1 has been implicated in developmental disorders, skin pathologies, and cancers, particularly those linked to RA imbalance.
The antibody enables researchers to investigate CYP26C1's expression, localization, and function in biological samples using techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It is essential for elucidating the enzyme's role in RA-dependent processes, such as neurogenesis, limb development, and epithelial cell regulation. Commercial CYP26C1 antibodies are typically validated for specificity and sensitivity, often targeting unique epitopes within the protein. Their applications extend to drug development studies, particularly for therapies targeting RA metabolism in cancer or inflammatory diseases. Understanding CYP26C1 through antibody-based research contributes to insights into cellular retinoid homeostasis and its therapeutic implications.
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