| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EDSC |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human COL5A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COL5A2抗体的3篇参考文献示例(内容基于典型研究领域，非真实文献)：
1. **文献名称**：*"Immunohistochemical localization of collagen α2(V) chain in human tissues using a novel COL5A2-specific antibody"*
**作者**：Miller, J. et al.
**摘要**：开发了一种高特异性兔抗人COL5A2多克隆抗体，验证其在多种组织中的表达模式，揭示COL5A2在皮肤、血管基质中的广泛分布，并探讨其与结缔组织疾病的相关性。
2. **文献名称**：*"COL5A2 as a potential biomarker in triple-negative breast cancer: Antibody-based proteomic analysis"*
**作者**：Chen, L. et al.
**摘要**：通过抗COL5A2单克隆抗体进行蛋白质组学分析，发现COL5A2在三阴性乳腺癌中显著高表达，与肿瘤侵袭性相关，提示其作为治疗靶点的潜力。
3. **文献名称**：*"Antibody-mediated disruption of COL5A2 alters extracellular matrix mechanics in fibroblast models"*
**作者**：Garcia, R. et al.
**摘要**：利用抗COL5A2功能阻断性抗体，研究其对成纤维细胞外基质力学性质的影响，发现COL5A2缺失导致胶原纤维排列紊乱，影响细胞迁移与组织修复。
(注：以上文献为示例，实际研究需通过PubMed、Web of Science等数据库检索具体论文。)
The COL5A2 antibody targets the α2 chain of type V collagen, a fibrillar collagen encoded by the COL5A2 gene. Type V collagen is a minor component of the extracellular matrix (ECM) and primarily forms heterotypic fibrils with type I collagen, playing a critical role in regulating fibril diameter and organization during collagen assembly. COL5A2 is expressed in tissues rich in connective tissue, such as skin, tendons, and blood vessels, where it contributes to structural integrity and mechanical stability.
Antibodies against COL5A2 are utilized in research to study its expression patterns, distribution, and involvement in diseases. Mutations in COL5A2 are linked to Ehlers-Danlos syndrome (EDS), a connective tissue disorder characterized by skin hyperelasticity, joint hypermobility, and tissue fragility. Additionally, altered COL5A2 expression has been observed in cancers, fibrosis, and wound healing, suggesting roles in tumor progression and ECM remodeling.
These antibodies enable detection via techniques like immunohistochemistry, Western blotting, and immunofluorescence, aiding in the investigation of COL5A2's functional interactions and pathological mechanisms. Research using COL5A2 antibodies also explores its potential as a biomarker or therapeutic target in connective tissue disorders and cancer.
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