| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NB-2; HNB-2s |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CNTN5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CNTN5抗体的模拟参考文献示例(请注意，以下内容为假设性示例，实际文献需通过学术数据库检索获取)：
1. **"CNTN5 Antibody Reveals Altered Expression in Autism Spectrum Disorder Models"**
*Author: Smith J, et al. (2020)*
**摘要**：本研究利用特异性CNTN5抗体检测自闭症模型小鼠脑组织，发现CNTN5蛋白在皮层及海马区表达显著降低，提示其可能与突触功能异常相关。
2. **"Development of a Novel CNTN5 Monoclonal Antibody for Glioblastoma Biomarker Screening"**
*Author: Lee H, et al. (2019)*
**摘要**：团队开发了一种高亲和力CNTN5单克隆抗体，应用于胶质母细胞瘤患者组织样本，证实CNTN5高表达与肿瘤侵袭性正相关，或成为潜在治疗靶点。
3. **"CNTN5 Antibody Blockade Impairs Neuronal Regeneration in Zebrafish"**
*Author: Garcia R, et al. (2018)*
**摘要**：通过抗体阻断CNTN5功能，发现斑马鱼周围神经再生能力受损，表明CNTN5在轴突导向中起关键作用，为神经修复研究提供新方向。
4. **"Structural Characterization of CNTN5 Epitopes Using Phage Display-Derived Antibodies"**
*Author: Wang T, et al. (2021)*
**摘要**：采用噬菌体展示技术筛选CNTN5抗体，解析其结合表位结构，为开发针对CNTN5相关疾病的诊断工具奠定分子基础。
**提示**：实际文献需通过PubMed、Web of Science等平台以关键词“CNTN5 antibody”检索，并筛选应用类或机制研究类论文。
CNTN5 (Contactin-5), a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules, plays critical roles in neuronal development, synaptic organization, and neural network formation. It is predominantly expressed in the central and peripheral nervous systems, where it mediates cell-cell interactions through homophilic or heterophilic binding, often partnering with receptor-type tyrosine phosphatases like PTPRG. CNTN5 is implicated in axon guidance, myelination, and plasticity, with emerging links to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia.
Antibodies targeting CNTN5 are essential tools for investigating its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to map CNTN5 distribution in neural tissues or assess its levels in disease models. Researchers also employ CNTN5 antibodies to study its interactions with binding partners (e.g., amyloid precursor protein (APP)) and its role in signaling pathways.
Recent studies highlight CNTN5's potential as a biomarker or therapeutic target, driving demand for high-specificity antibodies. Commercially available CNTN5 antibodies are typically validated in knockout models or siRNA-mediated knockdown systems to confirm target specificity. However, variability in antibody performance across applications necessitates careful optimization. Ongoing research using these antibodies aims to unravel CNTN5's contributions to neural circuit dysregulation in psychiatric diseases and its broader implications in neurodegenerative conditions.
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