| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MSG1 |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CITED1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CITED1抗体的3篇文献概览(虚构示例，仅供参考格式)：
1. **文献名称**：CITED1 as a Marker for Renal Cell Carcinoma
**作者**：Mao Y, et al.
**摘要**：研究通过免疫组化验证CITED1抗体在肾透明细胞癌中的特异性表达，发现其可作为区分肾癌与正常肾组织的生物标志物。
2. **文献名称**：Developmental Role of CITED1 in Mammalian Organogenesis
**作者**：Bochert R, et al.
**摘要**：利用CITED1抗体进行Western blot和免疫荧光，揭示CITED1在小鼠胚胎肾脏发育中的调控作用，与Wnt/β-catenin通路相关。
3. **文献名称**：CITED1 Interaction with Transcriptional Coactivators
**作者**：Valenta T, et al.
**摘要**：通过免疫沉淀和抗体阻断实验，证明CITED1通过结合p300/CBP影响靶基因转录，参与肿瘤微环境调控。
(注：以上为示例框架，实际文献需通过PubMed或Google Scholar检索关键词“CITED1 antibody” + “application”获取。)
CITED1 (CBP/p300-interacting transactivator with ED-rich tail 1) is a transcriptional co-regulator involved in modulating gene expression during development and cellular differentiation. It interacts with transcriptional coactivators CBP/p300. influencing the assembly of transcriptional complexes. CITED1 is notably expressed in embryonic tissues, playing roles in kidney development, mammary gland morphogenesis, and melanocyte biology. Its activity is linked to key signaling pathways, including Wnt/β-catenin and HIF-1α, where it either enhances or represses target gene transcription depending on cellular context.
In research, CITED1 antibodies are widely used to study its expression patterns and functional roles. Immunohistochemical studies highlight its tissue-specific expression, such as in nephron progenitor cells during kidney development or in subsets of breast cancers. CITED1 has emerged as a biomarker in certain pathologies; for example, it is overexpressed in Wilms' tumor and some breast carcinomas, correlating with clinical outcomes. Antibodies against CITED1 enable detection via techniques like Western blot, immunofluorescence, and flow cytometry, aiding in mechanistic studies of its dual roles in development and oncogenesis.
Structurally, CITED1 contains conserved domains (CR1. CR2. CR3) that mediate interactions with CBP/p300 and other partners. Its C-terminal acidic region is critical for transcriptional modulation. Research using CITED1 antibodies continues to unravel its context-dependent functions, offering insights into developmental biology and potential therapeutic targets in cancer.
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