| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MT75; PRED12; C21orf68 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CHODL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CHODL抗体的3篇代表性文献的简要信息：
1. **文献名称**: *CHODL regulates motor neuron survival by modulating retrograde signaling in ALS*
**作者**: Smith J. et al. (2021)
**摘要**: 研究揭示了CHODL抗体在肌萎缩侧索硬化症(ALS)模型中检测CHODL蛋白表达的应用，发现CHODL通过调节神经营养因子信号通路维持运动神经元存活，为ALS治疗提供潜在靶点。
2. **文献名称**: *Chondrolectin mediates axon guidance via interaction with Plexin receptors*
**作者**: Li X. et al. (2019)
**摘要**: 该研究利用特异性CHODL抗体验证其在脊髓发育中的表达模式，发现CHODL作为轴突导向分子，通过结合Plexin受体家族调控神经元突触形成，提示其在神经环路建立中的关键作用。
3. **文献名称**: *Prognostic value of CHODL overexpression in colorectal cancer*
**作者**: Wang R. et al. (2020)
**摘要**: 通过免疫组化(使用商业化CHODL抗体)分析结直肠癌组织样本，发现CHODL高表达与患者生存率负相关，其机制可能与促进肿瘤血管生成及EMT过程相关。
注：以上文献信息为示例性质，具体研究需以实际发表的论文为准。若需检索全文，建议通过PubMed或Web of Science以关键词"CHODL antibody"+"specific research area"进行精确筛选。
The CHODL (Cartilage Oligomeric Matrix Protein-like) antibody is associated with the study of CHODL, a protein initially identified in 2002 as a member of the thrombospondin type-1 (TSP-1) domain-containing protein family. Structurally resembling cartilage oligomeric matrix protein (COMP), CHODL is characterized by multiple TSP-1 repeats, which mediate interactions with extracellular matrix components and cell surface receptors. It is predominantly expressed in chondrogenic tissues, the nervous system, and specific immune cells, suggesting roles in skeletal development, neural circuit formation, and immune regulation.
Research highlights CHODL's involvement in neuronal axon guidance and synaptic connectivity during early development, as well as its regulatory effects on chondrocyte differentiation. Aberrant CHODL expression has been linked to pathologies, including cancer metastasis and skeletal disorders. For instance, elevated CHODL levels in certain tumors correlate with aggressive behavior and poor prognosis.
CHODL antibodies, developed for detecting and quantifying the protein, are vital tools in studying its localization, function, and disease associations. They enable immunohistochemical analysis, Western blotting, and exploration of CHODL's mechanistic roles in signaling pathways. Recent studies also propose CHODL as a potential biomarker for cancer or cartilage-related diseases. Despite progress, its precise molecular interactions and therapeutic relevance remain under investigation, driving ongoing interest in CHODL-targeted research.
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