Rabbit Polyclonal OTUD7B Antibody

The OTUD7B antibody is a research tool designed to target OTUD7B (OTU deubiquitinase 7B), a member of the OTU subfamily of deubiquitinating enzymes (DUBs). DUBs regulate cellular processes by removing ubiquitin chains from substrate proteins, modulating protein stability, localization, and interactions. OTUD7B, also known as Cezanne2. contains a conserved OTU domain critical for its catalytic activity. It selectively cleaves lysine-11-linked polyubiquitin chains, distinguishing it from other DUBs. Studies suggest OTUD7B plays roles in immune signaling, apoptosis, and cancer progression. For instance, it negatively regulates NF-κB signaling by deubiquitinating key mediators, influencing inflammatory responses. Dysregulation of OTUD7B has been linked to diseases, including cancers and autoimmune disorders, though its mechanisms remain under investigation. The OTUD7B antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study its expression, subcellular localization, and interaction partners. Researchers also employ it to explore OTUD7B's therapeutic potential, particularly in contexts where ubiquitination pathways are disrupted. Its specificity and validation in multiple experimental models make it essential for deciphering OTUD7B's biological and pathological roles.