| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | iCE; CE-2; PCE-2; CES2A1 |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CES2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CES2抗体的参考文献示例(内容基于模拟生成，建议核实真实文献)：
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1. **文献名称**: "Characterization of a Novel Monoclonal Antibody for Human Carboxylesterase 2 (CES2) and Its Application in Immunohistochemistry"
**作者**: Smith A, et al.
**摘要**: 该研究开发了一种高特异性抗人CES2单克隆抗体，验证了其在结肠癌及肝组织样本中的免疫组化应用，证实CES2在肿瘤微环境中的差异表达与化疗药物代谢相关。
2. **文献名称**: "CES2 Expression Profiling in Pancreatic Cancer Using a Validated Polyclonal Antibody"
**作者**: Lee J, et al.
**摘要**: 通过多克隆抗体分析胰腺癌组织中的CES2蛋白水平，发现其高表达与伊立替康药物敏感性升高相关，提示CES2可作为个性化治疗的潜在生物标志物。
3. **文献名称**: "Development of a Sensitive ELISA for Quantifying CES2 in Human Plasma"
**作者**: Wang Y, et al.
**摘要**: 研究团队基于兔源CES2多抗建立了一种ELISA检测方法，用于定量人血浆中的CES2浓度，为评估代谢疾病患者肝脏功能提供了新工具。
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如需具体文献，建议通过PubMed或Web of Science以“CES2 antibody”或“carboxylesterase 2 immunohistochemistry”为关键词检索近年研究。
Carboxylesterase 2 (CES2) is a key enzyme belonging to the carboxylesterase family, primarily involved in hydrolyzing ester-containing compounds, including prodrugs, environmental toxins, and endogenous lipids. It is highly expressed in the liver, gastrointestinal tract, and kidneys, playing a critical role in drug metabolism, lipid homeostasis, and detoxification. CES2 has gained attention for its role in activating anticancer prodrugs like irinotecan, where its activity directly impacts therapeutic efficacy and toxicity.
CES2 antibodies are essential tools for studying the enzyme's expression, localization, and function in both physiological and pathological contexts. They enable researchers to investigate tissue-specific expression patterns, correlate enzyme levels with disease progression (e.g., in colorectal cancer or liver disorders), and assess interindividual variability in drug responses. Such antibodies are typically validated for applications like Western blotting, immunohistochemistry, and ELISA.
Challenges in CES2 antibody development include ensuring specificity due to structural similarities with other carboxylesterases, particularly CES1. High-quality antibodies must distinguish between isoforms to avoid cross-reactivity, which is critical for accurate diagnostic or research outcomes. Ongoing research focuses on refining antibody specificity and exploring CES2's potential as a biomarker or therapeutic target in metabolic diseases and oncology.
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