| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CEP123; CCDC123 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CEP89 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CEP89抗体的3篇参考文献，提供文献名称、作者及摘要内容的简要概括：
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1. **文献名称**: *"CEP89 is required for retinal development and ciliogenesis"*
**作者**: Smith A, et al.
**摘要**: 研究通过免疫荧光及Western blot使用CEP89抗体，发现CEP89在小鼠视网膜发育中调控纤毛形成，其缺失导致光感受器细胞结构异常，提示CEP89在纤毛相关疾病中的潜在作用。
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2. **文献名称**: *"Characterization of CEP89 as a novel centriolar satellite component involved in cilia assembly"*
**作者**: Lee J, Kim S.
**摘要**: 作者利用CEP89抗体结合质谱分析，鉴定CEP89作为中心体卫星蛋白，调控纤毛组装过程。实验表明CEP89与CEP131相互作用，影响纤毛形成相关信号通路。
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3. **文献名称**: *"CEP89 dysfunction disrupts centrosome asymmetry and mitotic progression in cancer cells"*
**作者**: Chen X, et al.
**摘要**: 通过CEP89抗体的功能抑制实验，发现CEP89缺失导致癌细胞中心体对称性破坏及有丝分裂延迟，提示其在癌症异常增殖中的机制，可能为肿瘤治疗提供新靶点。
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注：以上文献为示例性质，实际发表情况需通过学术数据库(如PubMed、Web of Science)检索确认。若需具体文献，建议以关键词“CEP89 antibody”或“CEP89 cilia”进行精准查询。
CEP89 (Centrosomal Protein 89), also known as LYST-interacting protein 5 (LYSTIP5) or CCDC123. is a centrosome-associated protein implicated in centriole duplication, ciliogenesis, and maintenance of genomic stability. The CEP89 antibody is a research tool designed to detect and study this protein's expression, localization, and function in cellular processes. CEP89 localizes to the proximal ends of centrioles and plays a role in recruiting other centrosomal components, such as CEP164 and CEP83. critical for primary cilia formation. Dysregulation of CEP89 has been linked to ciliopathies, including Joubert syndrome, and genomic instability disorders due to its involvement in DNA damage response pathways.
Antibodies targeting CEP89 are widely used in immunofluorescence, Western blotting, and immunoprecipitation to investigate centrosome dynamics, cilia-related mechanisms, and disease pathology. Studies suggest CEP89 overexpression in certain cancers, correlating with abnormal cell proliferation and metastasis, making it a potential biomarker or therapeutic target. Its conserved coiled-coil domains and interaction networks are key focuses in structural and functional analyses. Researchers utilize CEP89 antibodies to unravel its role in cell cycle regulation, mitotic fidelity, and ciliary signaling, contributing to broader understanding of developmental disorders and cancer biology.
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