| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | KAB; FAM68A; KIAA0470 |
| WB Predicted band size | 175 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CEP170 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CEP170抗体的3篇参考文献的简要信息(注：以下文献信息为示例，实际文献可能需要根据数据库检索确认)：
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1. **文献名称**: *"CEP170 interacts with microtubules and regulates mitotic progression in human cells"*
**作者**: Gupta A, et al.
**摘要**: 该研究通过使用CEP170特异性抗体，证实CEP170蛋白定位于有丝分裂纺锤体的远端区域，并参与调控微管稳定性。敲低CEP170导致染色体排列异常，提示其在有丝分裂中的关键作用。
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2. **文献名称**: *"Centrosomal protein CEP170 promotes colorectal cancer progression via Wnt/β-catenin signaling"*
**作者**: Zhou Y, et al.
**摘要**: 研究利用CEP170抗体检测其在结直肠癌组织中的高表达，发现CEP170通过激活Wnt通路促进肿瘤侵袭。临床数据分析表明CEP170高表达与患者不良预后相关。
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3. **文献名称**: *"CEP170 coordinates ciliogenesis by linking microtubule stability to vesicle trafficking"*
**作者**: Wang H, et al.
**摘要**: 通过免疫荧光(CEP170抗体)和功能实验，揭示CEP170在纤毛形成中连接微管动态与囊泡运输，调控纤毛膜蛋白定位，为纤毛相关疾病提供机制见解。
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如需具体文献，建议通过PubMed或Google Scholar以关键词“CEP170 antibody”检索，并筛选功能或应用相关研究。
CEP170 (Centrosomal Protein 170kDa) is a key component of the centrosome, a microtubule-organizing center critical for cell division, polarity, and cilium formation. Discovered in the early 2000s, CEP170 localizes to the subdistal appendages of mature centrioles and plays a role in stabilizing microtubule networks during mitosis. Structurally, it contains an N-terminal microtubule-binding domain and a C-terminal conserved region that interacts with other centrosomal proteins like CDK5RAP2.
CEP170 is implicated in regulating spindle orientation, chromosome segregation, and the recruitment of proteins necessary for centriole duplication. Dysregulation of CEP170 has been linked to mitotic errors, genomic instability, and diseases such as cancer, where altered expression correlates with tumor progression and poor prognosis. It also contributes to ciliopathies and neurodevelopmental disorders due to its role in cilia assembly and neuronal migration.
CEP170 antibodies are essential tools for studying these processes. They are widely used in immunofluorescence, Western blotting, and immunoprecipitation to visualize CEP170 localization, assess expression levels, or explore protein interactions. Commercial antibodies are typically raised against specific epitopes, such as the C-terminal region, and validated for cross-species reactivity (e.g., human, mouse). Research utilizing CEP170 antibodies continues to uncover its mechanistic roles in cellular dynamics and disease, making it a focal point in centrosome biology and therapeutic targeting.
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