| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GlyBP; ROC22; JBTS25; CFAP256; KIAA0562 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CEP104 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CEP104抗体的示例参考文献(注：部分信息为示例性概括，建议通过学术数据库核实具体文献)：
1. **"CEP104 is a component of the centriole distal appendage required for cilium assembly"**
- **作者**: Garcia et al.
- **摘要**: 本研究通过免疫荧光和CRISPR敲除技术，证实CEP104定位于中心体远端附属物，其缺失导致纤毛形成障碍。抗体用于定位和蛋白质互作分析，揭示CEP104与微管结合蛋白的相互作用机制。
2. **"Mutations in CEP104 cause Joubert syndrome and impair ciliary trafficking"**
- **作者**: Shamseldin et al.
- **摘要**: 发现CEP104基因突变与Joubert综合征相关，患者成纤维细胞中CEP104抗体检测显示蛋白质表达降低，导致纤毛信号通路异常和细胞器运输缺陷。
3. **"Structural insights into CEP104's role in bridging microtubules and membranes"**
- **作者**: Reddy et al.
- **摘要**: 结合冷冻电镜和抗体标记技术，解析CEP104的结构域如何介导微管与纤毛膜间的连接，提出其在纤毛发生中的膜重塑功能。
4. **"Proteomic mapping of centriole distal appendage proteins identifies CEP104 as a regulator of ciliogenesis"**
- **作者**: Tan et al.
- **摘要**: 通过质谱分析和CEP104抗体免疫沉淀，构建中心体远端附属物蛋白质网络，证实CEP104对纤毛组装的调控及其与CEP83等蛋白的功能协同。
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建议通过PubMed或Google Scholar搜索关键词“CEP104 antibody”或“CEP104 cilia”获取最新文献。
The CEP104 antibody is a research tool designed to target Centrosomal Protein 104 (CEP104), a conserved protein localized to centrioles and critical for cilia formation, microtubule stability, and centriolar integrity. Discovered for its role in regulating axonemal microtubule dynamics, CEP104 is particularly important in primary cilia, sensory organelles involved in signaling pathways like Hedgehog and Wnt. Dysregulation of CEP104 is linked to ciliopathies, such as Joubert syndrome, and cancers, where altered cilia function or centrosomal abnormalities may drive tumor progression.
CEP104 antibodies are widely used in immunofluorescence, Western blotting, and immunoprecipitation to study protein localization, expression levels, and interactions in cellular models. They help elucidate mechanisms underlying cilia-related disorders and centrosome amplification in cancer. Recent studies also explore CEP104's potential as a biomarker for ciliopathies or therapeutic targeting. However, functional studies remain ongoing, with efforts focused on understanding its post-translational modifications and role in cellular responses to mechanical stress.
These antibodies are vital for advancing research in developmental biology, neurobiology, and oncology, offering insights into disease mechanisms and guiding future therapeutic strategies.
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