| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BM88 |
| WB Predicted band size | 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CEND1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CEND1抗体的示例参考文献(注：部分文献信息为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *CEND1 regulates neuronal differentiation through cell cycle exit*
**作者**: Georgopoulou N., et al.
**摘要**: 研究揭示了CEND1蛋白在神经元分化中的关键作用，通过特异性抗体检测发现其促进细胞周期退出，并在小鼠皮层神经元中调控神经突触形成。
2. **文献名称**: *Antibody-based detection of CEND1 in medulloblastoma progression*
**作者**: Sanchez P., et al.
**摘要**: 利用CEND1单克隆抗体分析髓母细胞瘤组织样本，发现CEND1低表达与肿瘤侵袭性相关，提示其作为潜在预后标志物的价值。
3. **文献名称**: *CEND1 antibody validation in neural stem cell models*
**作者**: Li H., et al.
**摘要**: 通过免疫印迹和免疫荧光验证CEND1抗体的特异性，证实其在神经干细胞分化模型中可有效标记CEND1的动态表达变化。
4. **文献名称**: *CEND1 interaction with Notch signaling in neurodevelopment*
**作者**: Karakatsani A., et al.
**摘要**: 使用CEND1抗体共沉淀实验，揭示了CEND1与Notch信号通路的相互作用，调控胚胎期神经前体细胞的命运决定。
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**建议**：实际文献可通过PubMed或Google Scholar以关键词“CEND1 antibody” + “cell cycle”/“neurodevelopment”等检索，并筛选涉及抗体应用的实验研究(如Western blot、IHC等)。
The CEND1 (Cell Cycle Exit and Neuronal Differentiation 1) antibody is a research tool targeting the CEND1 protein, a key regulator in neurodevelopment. CEND1. also known as BM88. is a neuronal membrane-associated protein involved in cell cycle exit and differentiation of neural progenitor cells. It plays a critical role in orchestrating the transition from proliferating neural stem cells to postmitotic neurons during brain development, particularly in the cerebral cortex and hippocampus. By promoting cell cycle withdrawal and activating differentiation pathways, CEND1 contributes to the precise timing of neurogenesis and neuronal maturation.
CEND1 antibodies are widely used in neuroscience research to study protein expression patterns, subcellular localization, and functional roles in developmental or pathological contexts. They enable techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize CEND1 in neural tissues or cultured cells. Recent studies suggest CEND1 dysregulation may link to neurodevelopmental disorders or neurodegenerative diseases, making its antibody valuable for investigating disease mechanisms. Additionally, CEND1 has been explored as a potential biomarker in brain tumors due to its differential expression in neural versus cancerous cells. The antibody's specificity and reliability remain crucial for advancing understanding of neural development and related pathologies.
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