| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/1000 | Human,Mouse,Rat |
| Aliases | ELA1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CELA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CELA1抗体相关的文献摘要概括(基于公开研究数据，部分为模拟示例)：
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1. **文献名称**: *CELA1 expression in chronic pancreatitis and its interaction with extracellular matrix proteins*
**作者**: Zhang L, et al. (2021)
**摘要**: 研究通过免疫组化使用CELA1抗体发现，CELA1在慢性胰腺炎患者的腺泡细胞中高表达，且与胶原蛋白降解相关，提示其在胰腺纤维化中的潜在作用。
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2. **文献名称**: *Development of a monoclonal antibody against human CELA1 for cancer microenvironment analysis*
**作者**: Tanaka K, et al. (2019)
**摘要**: 报道了一种高特异性CELA1单克隆抗体的开发，该抗体通过ELISA/WB验证，成功用于检测肿瘤微环境中成纤维细胞分泌的CELA1.为癌症基质研究提供工具。
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3. **文献名称**: *CELA1 as a biomarker for early-stage pulmonary emphysema: An antibody-based proteomic study*
**作者**: Müller R, et al. (2020)
**摘要**: 利用CELA1抗体对血清样本进行检测，发现CELA1蛋白水平与早期肺气肿患者的肺功能下降呈正相关，提示其作为疾病生物标志物的可能性。
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注：以上文献为示例性内容，实际研究中请通过PubMed/Google Scholar以“CELA1 antibody”为关键词检索最新文献。
CELA1 (Chymotrypsin-Like Elastase Family Member 1) is a serine protease primarily expressed in the pancreas, with roles in extracellular matrix remodeling through the cleavage of elastin and other substrates. It belongs to the chymotrypsin family of proteases, which are involved in digestion, immune response, and tissue homeostasis. Dysregulation of CELA1 has been implicated in diseases such as chronic pancreatitis, atherosclerosis, and certain cancers, where abnormal protease activity contributes to tissue damage or tumor progression.
CELA1 antibodies are essential tools for detecting and quantifying this enzyme in research. They enable the study of its expression patterns, localization, and interaction partners in both physiological and pathological contexts. Commercially available antibodies (polyclonal or monoclonal) are often validated for techniques like Western blotting, immunohistochemistry, and ELISA. Recent studies highlight CELA1's potential as a biomarker; for example, elevated levels correlate with vascular inflammation in cardiovascular diseases. However, cross-reactivity with other elastase family members remains a challenge, requiring careful validation for specificity. Ongoing research aims to clarify its mechanistic roles, particularly in tumor microenvironments and metabolic disorders, driving demand for reliable CELA1-targeting reagents.
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