| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CDHB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CDH12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDH12抗体的3篇参考文献示例(注：以下文献信息为模拟示例，仅供参考，实际引用时请核实原文准确性)：
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1. **文献名称**: *CDH12-mediated cell adhesion regulates glioblastoma invasion*
**作者**: Smith A, et al.
**摘要**: 研究CDH12在胶质母细胞瘤侵袭中的作用，通过特异性抗体进行免疫组化分析，发现CDH12高表达与肿瘤细胞迁移能力增强相关，提示其作为潜在治疗靶点。
2. **文献名称**: *Expression profiling of cadherin-12 in the developing mouse brain*
**作者**: Lee J, Kim D.
**摘要**: 利用CDH12抗体进行小鼠脑发育阶段的免疫荧光染色，揭示CDH12在海马体和小脑颗粒细胞中的动态表达模式，支持其在神经回路形成中的功能。
3. **文献名称**: *CDH12 as a novel biomarker in triple-negative breast cancer*
**作者**: Garcia R, et al.
**摘要**: 通过Western blot和免疫组织化学(使用CDH12抗体)发现，CDH12在三阴性乳腺癌中显著上调，与患者预后不良相关，可能参与肿瘤转移调控。
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如需进一步文献检索，建议使用PubMed或Web of Science以关键词“CDH12 antibody”或“Cadherin-12”进行查询。
The CDH12 antibody targets cadherin-12 (CDH12), a calcium-dependent cell adhesion molecule belonging to the type-II classical cadherin family. Cadherins play critical roles in tissue morphogenesis, cell-cell adhesion, and signaling. CDH12 is primarily expressed in the nervous system, where it contributes to neural circuit formation, synaptic plasticity, and neuronal migration during development. It is also implicated in cancer progression, particularly in malignancies like glioblastoma and breast cancer, where aberrant CDH12 expression correlates with tumor invasiveness and metastasis.
CDH12 antibodies are essential tools for studying its localization, expression levels, and functional interactions in both physiological and pathological contexts. They are widely used in techniques such as immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF) to investigate CDH12's role in neural development, cancer biology, and neurodegenerative disorders. Recent research explores CDH12's potential as a biomarker or therapeutic target, given its involvement in cell adhesion pathways and epithelial-mesenchymal transition (EMT). However, its precise mechanisms remain under investigation, necessitating high-specificity antibodies to minimize cross-reactivity with other cadherins. Commercial CDH12 antibodies are typically validated for human, mouse, and rat samples, supporting translational research across model systems.
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