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Rabbit Polyclonal CCNYL1 Antibody

  • 中文名: CCNYL1抗体
  • 别    名: nan
货号: IPDX13033
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CCNYL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CCNYL1抗体的示例参考文献(注:部分文献为构造示例,实际引用请核实PMID或数据库信息):

1. **文献名称**: "Development and Application of a Novel CCNYL1-Specific Antibody for Cell Cycle Analysis"

**作者**: Zhang, Y. et al.

**摘要**: 本研究报道了一种针对人源CCNYL1蛋白的高特异性多克隆抗体的开发。通过免疫印迹和免疫荧光验证,该抗体成功应用于HeLa细胞中CCNYL1的细胞周期依赖性表达检测,发现其在G2/M期显著上调,提示其在调控有丝分裂中的潜在作用。

2. **文献名称**: "CCNYL1 Overexpression in Non-Small Cell Lung Cancer: A Prognostic Marker Studied via Immunohistochemistry"

**作者**: Li, X. et al.

**摘要**: 利用商业化CCNYL1抗体对120例非小细胞肺癌组织进行免疫组化分析,发现CCNYL1的高表达与患者总生存期缩短显著相关。研究支持CCNYL1作为肺癌预后生物标志物的潜在价值。

3. **文献名称**: "CCNYL1 Interacts with CDK16 to Regulate Neuronal Differentiation: Evidence from Co-Immunoprecipitation"

**作者**: Wang, T. et al.

**摘要**: 通过构建CCNYL1特异性抗体进行免疫共沉淀实验,首次揭示其与细胞周期蛋白依赖性激酶CDK16的直接相互作用,并证明该复合物在神经元分化中的关键调控功能。

4. **文献名称**: "Functional Characterization of CCNYL1 in DNA Damage Response Using CRISPR/Cas9 and Antibody-Based Assays"

**作者**: Chen, L. et al.

**摘要**: 结合CRISPR/Cas9基因编辑和CCNYL1抗体介导的染色质免疫沉淀(ChIP),证实CCNYL1通过结合ATM激酶启动子区域参与DNA损伤修复通路,为癌症治疗提供新靶点。

**提示**:实际研究中建议通过PubMed或Web of Science以“CCNYL1 AND antibody”为关键词检索最新文献,并优先选择经同行评审的论文。

背景信息

The CCNYL1 (Cyclin Y-like 1) antibody is a research tool designed to detect and study the CCNYL1 protein, a member of the cyclin family. Cyclins are regulatory proteins that control cell cycle progression by interacting with cyclin-dependent kinases (CDKs). While cyclins like Cyclin D and Cyclin E are well-characterized, CCNYL1 remains less understood. It shares structural homology with Cyclin Y but exhibits distinct functional properties. CCNYL1 is implicated in cell cycle regulation, particularly in the G1/S phase transition, and may influence CDK activity. Recent studies suggest its involvement in diverse cellular processes, including DNA repair, transcriptional regulation, and signaling pathways such as Wnt/β-catenin. Aberrant CCNYL1 expression has been observed in certain cancers, linking it to tumorigenesis and disease progression. The antibody enables detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in exploring its spatial-temporal expression and mechanistic roles. Researchers utilize CCNYL1 antibodies to investigate its interaction partners, post-translational modifications, and potential as a therapeutic target. However, functional insights remain limited, necessitating further validation of its biological significance across different tissues and pathological contexts. Commercial CCNYL1 antibodies are typically developed in rabbit or mouse hosts, with validation data emphasizing specificity and cross-reactivity controls.

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