| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LRPDIT; LRP-DIT |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LRP1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于LRP1B抗体的参考文献示例(注：文献为虚构示例，仅供格式参考)：
---
1. **"LRP1B Antibody Development for Tumor Suppressor Functional Analysis"**
*Authors: Smith J, Lee R, Garcia M*
**摘要**：本研究开发并验证了一种高特异性LRP1B单克隆抗体，用于检测多种癌症细胞系中LRP1B蛋白的表达。通过免疫印迹和免疫荧光实验，发现LRP1B在肺癌和乳腺癌中显著低表达，其缺失与肿瘤侵袭性增强相关。
2. **"LRP1B as a Biomarker in Colorectal Cancer: An Immunohistochemical Study"**
*Authors: Zhang Y, Wang H, Liu X*
**摘要**：利用抗LRP1B抗体对结直肠癌组织进行免疫组化分析，发现LRP1B表达水平与患者生存率呈正相关。研究提示LRP1B可作为预后标志物，并可能参与抑制Wnt/β-catenin信号通路。
3. **"Epigenetic Regulation of LRP1B and Antibody-Based Therapeutic Potential"**
*Authors: Kim S, Patel A, Nguyen T*
**摘要**：通过抗LRP1B抗体检测发现，启动子甲基化导致LRP1B在卵巢癌中沉默。研究进一步探索了LRP1B抗体偶联纳米颗粒的靶向治疗潜力，证实其在体外抑制肿瘤生长。
4. **"Validation of Commercial LRP1B Antibodies for Functional Genomics"**
*Authors: Müller C, Braun F, Schmidt D*
**摘要**：系统评估了市售LRP1B抗体的特异性与灵敏度，发现部分抗体存在交叉反应性。研究为LRP1B功能基因组学实验提供了可靠的抗体选择标准，并揭示了其在神经母细胞瘤中的潜在抑癌作用。
---
**说明**：以上文献为模拟示例，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。建议使用关键词“LRP1B antibody validation”、“LRP1B cancer biomarker”等进行精确查询。
The LRP1B (low-density lipoprotein receptor-related protein 1B) antibody is a tool used to study the LRP1B protein, a member of the LDL receptor family. LRP1B is a transmembrane receptor implicated in cellular signaling, endocytosis, and lipid metabolism. It shares structural homology with LRP1 but is distinguished by its large size and unique ligand-binding domains. Research highlights LRP1B's role as a putative tumor suppressor, frequently silenced or deleted in cancers such as lung, breast, and gastric carcinomas, suggesting its involvement in tumorigenesis suppression and metastasis regulation.
Antibodies targeting LRP1B enable detection of its expression and localization in tissues or cell lines, aiding investigations into its molecular interactions and pathways. These antibodies are utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using LRP1B antibodies have revealed reduced protein levels in certain cancers, correlating with poor prognosis. Additionally, LRP1B's interaction with extracellular matrix components and signaling molecules (e.g., Wnt, TGF-β) underscores its regulatory role in cellular adhesion and proliferation.
Despite its significance, LRP1B's precise mechanisms remain partially elusive. Antibody validation is critical due to potential cross-reactivity with homologous proteins. Ongoing research focuses on clarifying LRP1B's tumor-suppressive functions and its potential as a therapeutic target or biomarker, emphasizing the antibody's utility in both basic and translational oncology contexts.
×
