| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TRIP3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ZNHIT3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNHIT3抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**: *ZNHIT3 is a novel partner of H2A.Z in promoting adipogenesis*
**作者**: Li Y, et al.
**摘要**: 本研究利用ZNHIT3特异性抗体，揭示了ZNHIT3通过结合组蛋白变体H2A.Z调控脂肪细胞分化的机制，发现其缺失会抑制脂肪生成相关基因的表达。
2. **文献名称**: *Proteomic analysis of ZNHIT3 interactions in chromatin remodeling complexes*
**作者**: Wang X, et al.
**摘要**: 通过免疫共沉淀(Co-IP)结合ZNHIT3抗体，鉴定了ZNHIT3在染色质重塑复合体中的新互作蛋白，提示其在DNA损伤修复和转录调控中的潜在功能。
3. **文献名称**: *ZNHIT3 antibody validation for immunohistochemistry in human hepatocellular carcinoma*
**作者**: Chen L, et al.
**摘要**: 该研究系统验证了ZNHIT3抗体在肝癌组织免疫组化中的特异性，发现ZNHIT3蛋白表达水平与患者预后显著相关，可能作为肝癌诊断标志物。
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注：以上文献为示例性概括，实际文献需通过PubMed或专业数据库(如Google Scholar)检索确认。若需具体文献链接或补充信息，可进一步说明。
ZNHIT3 (Zinc Finger HIT-Type Containing 3) is a protein encoded by the ZNHIT3 gene, belonging to the zinc finger HIT-type protein family. It is a component of the SNF2-related CREBBP activator protein (SRCAP) complex, which plays a critical role in chromatin remodeling by facilitating the deposition of the histone variant H2A.Z into nucleosomes. This process is essential for regulating gene expression, DNA repair, and maintaining genomic stability. ZNHIT3 specifically interacts with the SRCAP subunit, contributing to the complex's ability to catalyze ATP-dependent nucleosome repositioning.
Antibodies targeting ZNHIT3 are valuable tools for studying its expression, localization, and functional interactions in cellular processes. They are commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate ZNHIT3's role in chromatin dynamics, transcriptional regulation, and disease mechanisms. Dysregulation of ZNHIT3 has been implicated in cancers, developmental disorders, and neurological conditions, making its detection crucial for understanding pathological pathways. Commercial ZNHIT3 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown to ensure reliable experimental outcomes. Research on ZNHIT3 continues to expand, highlighting its potential as a therapeutic target or biomarker in diseases linked to epigenetic dysregulation.
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