| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NLZ1; ZPO1; ZEPPO1; ZNF503L |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ZNF703 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ZNF703抗体的3篇参考文献示例(注：文献信息为模拟生成，仅供参考)：
---
1. **文献名称**: *ZNF703 acts as an oncogene in breast cancer by regulating Notch signaling pathway*
**作者**: Liu J, et al.
**摘要**: 本研究利用ZNF703抗体通过免疫组化和Western blotting证实ZNF703在乳腺癌组织中高表达，并促进肿瘤细胞增殖和侵袭。机制研究表明ZNF703通过激活Notch信号通路驱动肿瘤进展。
---
2. **文献名称**: *ZNF703 as a potential biomarker in ovarian cancer: Insights from immunohistochemical analysis*
**作者**: Smith A, et al.
**摘要**: 通过ZNF703抗体进行免疫组织化学染色，发现ZNF703在高级别浆液性卵巢癌中显著过表达，且与患者预后不良相关，提示其可作为治疗靶点或诊断标志物。
---
3. **文献名称**: *Functional characterization of ZNF703 in lung adenocarcinoma using CRISPR/Cas9 and antibody-based knockdown*
**作者**: Zhang Y, et al.
**摘要**: 结合CRISPR/Cas9基因编辑和ZNF703抗体介导的蛋白敲低技术，证明ZNF703通过调控EGFR信号通路促进肺腺癌细胞存活和化疗耐药。
---
如需具体文献，建议通过PubMed或Google Scholar以“ZNF703 antibody”或“ZNF703 cancer”为关键词检索近年发表的论文。
The ZNF703 antibody is a key tool for studying the Zinc Finger Protein 703 (ZNF703), a member of the NET/NLZ family of transcriptional regulators. ZNF703. located on chromosome 8q21.13. has gained attention for its role in cancer biology, particularly in breast and ovarian cancers. It functions as a transcriptional repressor, interacting with chromatin-modifying complexes to regulate gene expression involved in cell proliferation, differentiation, and embryonic development. Amplification of the 8q region, leading to ZNF703 overexpression, is frequently observed in aggressive luminal B breast cancers, where it is implicated in tumor progression and therapy resistance.
The ZNF703 antibody is typically generated using recombinant ZNF703 protein or synthetic peptides as immunogens, with host species like rabbit or mouse. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ZNF703 expression levels in tissues or cell lines. Researchers employ this antibody to investigate ZNF703's oncogenic mechanisms, including its interaction with pathways like EZH2-mediated epigenetic regulation or RAC1-driven cell migration. Its validation often includes knockout/knockdown controls and correlation with clinical outcomes. As ZNF703 emerges as a potential biomarker and therapeutic target, its antibody remains critical for both basic research and translational studies in oncology.
×
