关键信息
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基因名
LINGO1
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简介
LINGO-1 protein is a functional component of the Nogo receptor signaling complex and activates RhoA, thereby inhibiting axonal regeneration through myelin-related factors. It is an important negative regulator of oligodendrocyte differentiation and axonal myelination. LINGO1 Protein, Human (HEK293, Llama Fc) is the recombinant human-derived LINGO1 protein, expressed by HEK293, with C-Llama Fc labeled tag.
- 应用
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别名
LERN1; L LRRN6A; L MRT64; L UNQ201
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种属
Human
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表达系统
HEK293
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标签
C-Llama Fc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96FE5-1
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表达区间
C42-T561
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蛋白长度
Extracellular Domain
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分子量
130-170 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
LINGO1 (Leucine-rich repeat and Ig-like domain-containing NOGO receptor-interacting protein 1) is a protein that has garnered significant attention in neuroscience and regenerative medicine due to its potential roles in axon growth inhibition and neural regeneration. Initially identified as an interacting partner of Nogo receptor, LINGO1 is believed to be involved in processes that regulate nervous system development and repair mechanisms following injury. Research has indicated that LINGO1 functions as a negative regulator of axonal regeneration, impacting the signaling pathways associated with myelin-associated inhibitors. This has led to an interest in developing LINGO1-targeted therapies to promote neural repair in conditions like spinal cord injuries and neurodegenerative diseases. Moreover, studies have linked LINGO1 to various neuropsychiatric disorders, suggesting that understanding its function and the modulation of its expression could have broader implications for mental health. Efforts to characterize and produce recombinant LINGO1 protein provide valuable insights into its structure-function relationship and facilitate the exploration of its therapeutic potential. The ongoing research into LINGO1 emphasizes its significance in advancing our understanding of neural communication and regeneration, positioning it as a promising target for interventions aimed at enhancing neural recovery and treating related disorders.
