| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HOX2; HOX2E; HOX-2.5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXB9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于HOXB9抗体的参考文献示例(注：文献信息为模拟虚构，仅供格式参考)：
1. **文献名称**: *HOXB9 as a Prognostic Biomarker in Breast Cancer*
**作者**: Smith A, et al.
**摘要**: 研究通过HOXB9抗体免疫组化分析，发现HOXB9在乳腺癌组织中的高表达与患者生存率降低及转移风险增加显著相关，提示其作为预后标志物的潜力。
2. **文献名称**: *HOXB9 Regulates Angiogenesis in Colorectal Cancer via VEGF Signaling*
**作者**: Chen L, et al.
**摘要**: 利用HOXB9抗体进行Western blot和免疫荧光实验，证实HOXB9通过调控VEGF通路促进结直肠癌血管生成，为靶向治疗提供理论依据。
3. **文献名称**: *Epigenetic Modulation of HOXB9 in Lung Adenocarcinoma*
**作者**: Tanaka K, et al.
**摘要**: 通过HOXB9抗体结合ChIP-seq技术，揭示DNA甲基化异常导致HOXB9在肺腺癌中过表达，并促进肿瘤细胞侵袭。
4. **文献名称**: *HOXB9 Antibody-Based Therapeutic Potential in Triple-Negative Breast Cancer*
**作者**: Gupta R, et al.
**摘要**: 研究使用HOXB9中和抗体抑制三阴性乳腺癌细胞增殖，证实靶向HOXB9可降低肿瘤生长速率，具有临床转化价值。
(注：实际文献需通过PubMed/Google Scholar等平台检索关键词"HOXB9 antibody"获取。)
**Background of HOXB9 Antibody**
HOXB9. a member of the Homeobox (HOX) gene family, encodes a transcription factor critical in embryonic development, particularly in establishing body patterning and tissue differentiation. HOX proteins regulate gene expression by binding to DNA, influencing cellular identity and morphogenesis. HOXB9 is notably involved in mammary gland development, hematopoiesis, and angiogenesis.
In cancer research, HOXB9 has gained attention due to its aberrant expression in malignancies like breast, lung, and colorectal cancers. Overexpression of HOXB9 is linked to tumor progression, metastasis, and therapy resistance, partly through promoting epithelial-mesenchymal transition (EMT) and angiogenesis. Its role in maintaining cancer stem cell properties further highlights its oncogenic potential.
HOXB9 antibodies are essential tools for detecting HOXB9 protein levels and localization in cells and tissues. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study HOXB9's biological functions and mechanisms in development and disease. Researchers also employ HOXB9 antibodies to explore its prognostic value in cancers or its interaction with regulatory pathways, aiding in the identification of therapeutic targets.
Overall, HOXB9 antibodies serve as vital reagents in both basic and translational research, bridging developmental biology and oncology.
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