| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | COX8-3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human COX8C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COX8C抗体的假设性参考文献示例(注：部分文献为模拟概括，实际引用需通过学术数据库验证)：
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1. **文献名称**: "A novel monoclonal antibody specific to human COX8C for mitochondrial complex IV analysis"
**作者**: Tanaka M, et al.
**摘要**: 该研究开发了一种高特异性的抗人COX8C单克隆抗体，验证了其在Western blot和免疫组化中的有效性，并用于分析不同细胞系中线粒体复合体IV的亚基组成。
2. **文献名称**: "COX8C expression profiling in mouse tissues using a validated polyclonal antibody"
**作者**: Lee S, et al.
**摘要**: 通过兔源多克隆抗体系统评估了COX8C在小鼠多种组织中的表达差异，揭示了其在心脏和骨骼肌中的高丰度表达，提示组织特异性代谢调控作用。
3. **文献名称**: "COX8C antibody reveals altered mitochondrial complex IV assembly in neurodegenerative models"
**作者**: Gomez-Castro F, et al.
**摘要**: 利用COX8C抗体研究神经退行性疾病模型中线粒体复合体IV的组装缺陷，发现COX8C表达下降与神经元能量代谢障碍相关。
4. **文献名称**: "Commercial antibody validation for COX8C: Pitfalls and solutions in cross-reactivity testing"
**作者**: Patel R, et al.
**摘要**: 分析了市售COX8C抗体的交叉反应性问题，提出通过CRISPR敲除细胞系验证抗体特异性，为精准检测提供方法学参考。
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**注意**：以上文献为模拟示例，实际研究中建议通过PubMed、Google Scholar等平台以关键词“COX8C antibody”或“COX8C immunohistochemistry”检索，或参考抗体供应商(如Abcam、CST)产品页引用的文献。若研究较少，可扩展至COX8C的功能研究或复合体IV亚基的通用抗体验证方法。
The COX8C antibody targets the cytochrome c oxidase subunit 8C (COX8C), a component of the mitochondrial respiratory chain complex IV (cytochrome c oxidase). This enzyme catalyzes the final step in the electron transport chain, transferring electrons to oxygen to form water while driving ATP synthesis. COX8C, one of several tissue-specific isoforms of subunit VIII, is primarily expressed in energy-demanding tissues such as heart, skeletal muscle, and testes. Its expression patterns and regulatory roles in mitochondrial metabolism have drawn interest in studies of cellular bioenergetics, metabolic disorders, and cancer.
COX8C antibodies are widely used as tools to investigate mitochondrial function, protein localization, and expression levels in both normal and pathological states. For example, research has linked altered COX8C expression to conditions like prostate cancer and Leigh syndrome, highlighting its potential as a biomarker. These antibodies are typically validated in applications such as Western blotting, immunofluorescence, and immunohistochemistry, often with species cross-reactivity (e.g., human, mouse, rat).
As mitochondrial dysfunction is implicated in aging and neurodegenerative diseases, COX8C antibodies also contribute to exploring therapeutic targets. Their specificity and reliability make them essential for dissecting the molecular mechanisms of oxidative phosphorylation and mitochondrial-associated pathologies.
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