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Rabbit Polyclonal GDF10 Antibody

  • 中文名: GDF10抗体
  • 别    名: BIP; BMP3B; BMP-3b
货号: IPDX12534
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesBIP; BMP3B; BMP-3b
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GDF10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于GDF10抗体的参考文献概览,涵盖其在神经修复、肌肉再生及疾病机制研究中的应用:

1. **"Growth differentiation factor 10 (GDF10) promotes post-stroke recovery through neuroprotective and regenerative mechanisms"**

- **作者**: Bespalov MM, et al.

- **摘要**: 该研究利用GDF10抗体进行免疫组织化学和Western blot分析,发现脑卒中后GDF10在损伤区域表达上调,并通过促进神经元存活和轴突再生改善功能恢复。抗体验证了其在神经修复模型中的关键作用。

2. **"GDF10 regulates skeletal muscle regeneration by modulating satellite cell activity"**

- **作者**: Zhang Y, et al.

- **摘要**: 通过GDF10抗体的阻断实验,研究发现GDF10通过激活卫星细胞促进肌肉再生。抗体用于检测肌肉损伤后GDF10的时空表达变化,证实其通过调控肌源性分化因子(如MyoD)发挥作用。

3. **"GDF10 as a therapeutic target in osteoarthritis: Antibody-based inhibition of cartilage degradation"**

- **作者**: Lee SJ, et al.

- **摘要**: 研究使用GDF10抗体抑制软骨细胞中GDF10活性,发现其可减少基质金属蛋白酶(MMP)的分泌,延缓骨关节炎进展。抗体实验支持GDF10在关节退行性病变中的促炎作用。

4. **"GDF10 suppresses breast cancer metastasis via EMT inhibition: Insights from antibody-based profiling"**

- **作者**: Chen X, et al.

- **摘要**: 该研究通过GDF10抗体检测肿瘤微环境中的蛋白表达,发现GDF10通过抑制上皮-间质转化(EMT)降低乳腺癌转移风险,抗体分析为靶向治疗提供了依据。

以上研究展示了GDF10抗体在疾病机制解析及治疗策略开发中的多样化应用。

背景信息

GDF10 (Growth Differentiation Factor 10), also known as bone morphogenetic protein 3B (BMP3B), is a member of the TGF-β superfamily involved in regulating cellular processes such as differentiation, apoptosis, and tissue repair. It plays roles in neural plasticity, metabolic regulation, and organ development. GDF10 antibodies are immunological tools designed to detect, quantify, or inhibit GDF10 protein activity in research and therapeutic contexts. These antibodies are crucial for studying GDF10's function in diseases like stroke, Alzheimer’s disease, and fibrosis, where its expression is often dysregulated. For instance, GDF10 is upregulated after brain injury, promoting neural repair, while in cancer, it may suppress metastasis by modulating epithelial-mesenchymal transition. Researchers employ GDF10 antibodies in techniques such as Western blotting, immunohistochemistry, and ELISA to analyze protein expression patterns or track therapeutic responses. Both monoclonal and polyclonal variants exist, with specificity validated through knockout controls or blocking assays. Recent studies also explore GDF10's potential as a therapeutic target, particularly in neuroregeneration and metabolic disorders, driving demand for high-affinity, selective antibodies. However, challenges remain in minimizing cross-reactivity with homologous proteins like BMP3. Overall, GDF10 antibodies serve as vital reagents for unraveling the protein's multifaceted roles and advancing translational applications.

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