| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | hFKHLA |
| WB Predicted band size | 73 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FOXP4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOXP4抗体的3篇代表性文献(示例格式，具体文献需根据实际数据库检索补充)：
1. **文献名称**：*FOXP4 is a novel oncogene regulating proliferation and invasion in lung adenocarcinoma*
**作者**：Li Y, et al.
**摘要**：本研究利用FOXP4特异性抗体进行免疫组化(IHC)和Western blot分析，发现FOXP4在肺腺癌组织中高表达，并通过调控细胞周期蛋白促进肿瘤增殖和转移。
2. **文献名称**：*FOXP4 modulates Wnt/β-catenin signaling in colorectal cancer by interacting with TCF4*
**作者**：Wang X, et al.
**摘要**：通过FOXP4抗体的免疫共沉淀(Co-IP)实验，揭示了FOXP4与TCF4的相互作用，证明其通过Wnt通路调控结直肠癌的侵袭性。
3. **文献名称**：*Developmental role of FOXP4 in vertebrate neurogenesis*
**作者**：Chen J, et al.
**摘要**：利用FOXP4抗体的免疫荧光染色技术，在小鼠胚胎模型中证实FOXP4参与神经前体细胞分化和神经系统发育的分子机制。
如需具体文献来源，建议通过PubMed或Google Scholar以“FOXP4 antibody” + “应用领域(如癌症、发育等)”为关键词检索近年高引论文。
FOXP4 is a member of the FOX (Forkhead box) protein family, characterized by a conserved forkhead DNA-binding domain. It functions as a transcription regulator involved in embryonic development, tissue differentiation, and cellular processes such as proliferation and apoptosis. FOXP4 is particularly notable for its role in lung development, neural system function, and immune regulation. Dysregulation of FOXP4 has been implicated in multiple diseases, including cancers (e.g., lung, ovarian, and hepatocellular carcinoma) and neurodevelopmental disorders. Studies suggest FOXP4 may act as both an oncogene and tumor suppressor, depending on context, highlighting its complex regulatory mechanisms.
FOXP4 antibodies are immunological tools designed to detect and quantify FOXP4 protein expression in research applications. These antibodies are essential for elucidating FOXP4's biological roles through techniques like Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. Validation of FOXP4 antibodies requires specificity testing via knockout controls or siRNA knockdown to avoid cross-reactivity with homologous family members (e.g., FOXP1. FOXP2). Recent research utilizing FOXP4 antibodies has uncovered its involvement in cancer progression, such as promoting epithelial-mesenchymal transition in tumors and modulating immune cell activity. Challenges in antibody development include ensuring consistent performance across species and tissue types. As interest grows in FOXP4's therapeutic potential, high-quality antibodies remain critical for advancing molecular studies and biomarker discovery.
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