| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ELK; NET; Hek6; EPHT2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human EPHB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于EPHB1抗体的参考文献示例(注：内容为假设性概括，仅供参考)：
1. **文献名称**：*EPHB1 regulates contact inhibition of proliferation in colorectal cancer cells*
**作者**：Smith A, et al.
**摘要**：通过EPHB1抗体进行Western blot和免疫荧光实验，发现EPHB1在结肠癌细胞中高表达，并通过抑制EGFR信号通路调控细胞增殖接触抑制。
2. **文献名称**：*EphB1 suppresses hepatocellular carcinoma metastasis via PI3K/AKT pathway*
**作者**：Zhang L, et al.
**摘要**：研究利用EPHB1抗体进行免疫组化分析，表明肝癌组织中EPHB1低表达与患者预后不良相关，并通过激活PI3K/AKT通路抑制肿瘤转移。
3. **文献名称**：*EphB1 modulates synaptic plasticity in hippocampal neurons*
**作者**：Brown K, et al.
**摘要**：采用EPHB1抗体阻断实验，发现EphB1受体通过调控NMDA受体活性影响海马神经元突触可塑性，揭示其在学习记忆中的作用。
4. **文献名称**：*Structural insights into EphB1-ephrin-B2 signaling complex*
**作者**：Wang Y, et al.
**摘要**：通过EPHB1抗体进行免疫共沉淀和冷冻电镜分析，解析了EphB1与ephrin-B2结合的分子结构，阐明其胞外域激活机制。
建议通过PubMed或Google Scholar以“EPHB1 antibody”和具体研究领域(如癌症、神经科学)为关键词检索真实文献。
**Background of EPHB1 Antibody**
The EPHB1 antibody is a tool used to detect and study EPHB1. a receptor tyrosine kinase belonging to the Eph receptor family. Eph receptors, divided into A and B subclasses based on ligand affinity, play critical roles in cell-cell communication, guiding processes like cell migration, axon guidance, and tissue patterning during development. EPHB1. a member of the B subclass, binds membrane-anchored ephrin-B ligands, triggering bidirectional signaling that regulates cell adhesion, repulsion, and spatial organization.
EPHB1 is implicated in diverse physiological and pathological contexts, including cancer progression, neurodevelopmental disorders, and vascular remodeling. In cancer, aberrant EPHB1 expression has been linked to tumor growth, metastasis, and angiogenesis in malignancies like colorectal carcinoma. In neuroscience, EPHB1 participates in synaptic plasticity and axon guidance, with potential roles in neurodegenerative diseases such as Alzheimer’s.
EPHB1 antibodies are essential for research applications like Western blotting, immunohistochemistry, and flow cytometry to localize and quantify EPHB1 expression in tissues or cells. They also facilitate functional studies, such as blocking receptor-ligand interactions to dissect signaling pathways. Both monoclonal and polyclonal EPHB1 antibodies are available, often validated for specificity and sensitivity. Recent advancements in recombinant antibody technology have improved their utility in therapeutic exploration, including targeting EPHB1 in precision oncology. Understanding EPHB1's role through antibody-based research continues to shed light on its biological significance and therapeutic potential.
×
