关键信息
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基因名
SHP-2
- 应用
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别名
(Protein-tyrosine phosphatase 1D)(PTP-1D)(Protein-tyrosine phosphatase 2C)(PTP-2C)(SH-PTP2)(SHP-2)(Shp2)(SH-PTP3)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q06124
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表达区间
2-593aa
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分子量
72.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SHP-2, or Src homology 2 domain-containing protein tyrosine phosphatase, plays a crucial role in various signaling pathways that regulate cell growth, differentiation, and survival. It is a non-receptor protein tyrosine phosphatase that is involved in mediating the effects of several growth factor receptors and cytokine signaling circuits, making it an essential player in hematopoiesis and immune responses. Dysregulation of SHP-2 activity has been linked to several diseases, including cancer, where its aberrant function often contributes to tumorigenesis and metastasis. Recent studies have focused on developing recombinant SHP-2 proteins for functional assays and the exploration of its interaction with different signaling molecules. Understanding the structure-function relationship of SHP-2 through recombinant protein studies is vital for elucidating its biological roles and could pave the way for the development of targeted therapies, especially in cancers characterized by its overactivation. Additionally, the manipulation of SHP-2 activity offers potential avenues for therapeutic intervention in various pathologies, underscoring the importance of continued research in this field.
