关键信息
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基因名
CSNK1G1
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简介
The CSNK1G1 protein is a member of the casein kinase family that preferentially phosphorylates acidic proteins, including casein, exhibiting broad substrate specificity. Functionally, it actively participates in the Wnt signaling pathway and regulates cellular responses. CSNK1G1 Protein, Human (sf9, His-GST) is the recombinant human-derived CSNK1G1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- 应用
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别名
Casein kinase I isoform gamma-1; CKI-gamma 1
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HCP0-1
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表达区间
M1-K422
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蛋白长度
Full Length of Isoform-1
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分子量
66 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CSNK1G1, or Casein Kinase I Gamma 1, is a serine/threonine kinase involved in crucial cellular processes, including signal transduction, cell cycle regulation, and circadian rhythm modulation. This enzyme is part of the Casein Kinase I family, which plays a significant role in phosphorylating various substrate proteins, thereby influencing their activity, stability, and localization. Studies have indicated that CSNK1G1 is associated with several diseases, including cancer and neurodegenerative disorders, making it a potential therapeutic target. Advances in recombinant protein technology have facilitated the production of CSNK1G1 in heterologous systems, allowing for detailed investigation of its biochemical properties and interactions. Understanding the structure and function of CSNK1G1 through recombinant protein studies can provide insights into its role in cellular signaling pathways and disease mechanisms. Furthermore, the development of specific inhibitors or modulators of CSNK1G1 could open new avenues for intervention in related pathologies. The exploration of this protein's function, dynamics, and regulatory mechanisms remains a critical area of research in molecular biology and pharmacology, highlighting its significance in both basic research and clinical applications.
